Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 12/20 | 0.77 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8739018 | 0.90 | EZH2 (0.68) | EZH2SLC6A5ATML3MBTL1GLA | |
| SCHEMBL8739028 | 0.87 | EZH2 (0.80) | EZH2SLC6A5ATML3MBTL1GLA | |
| SCHEMBL8738997 | 0.87 | EZH2 (1.00) | EZH2SLC6A5NPC1RAB9AALDH1A1 | |
| SCHEMBL8739679 | 0.86 | EZH2 (0.57) | EZH2SLC6A5NPC1RAB9AKDM4E | |
| SCHEMBL8738277 | 0.85 | EZH2 (0.77) | EZH2ALDH1A1ATML3MBTL1GLA | |
| SCHEMBL8739012 | 0.83 | EZH2 (0.67) | EZH2ATML3MBTL1GLAMEN1 | |
| SCHEMBL8738204 | 0.83 | EZH2 (0.69) | EZH2ATML3MBTL1GLAMEN1 | |
| SCHEMBL8738695 | 0.83 | EZH2 (0.91) | EZH2 | |
| SCHEMBL6121036 | 0.82 | EZH2 (0.78) | EZH2ATML3MBTL1GLAMEN1 | |
| SCHEMBL8738645 | 0.82 | EZH2 (0.81) | EZH2SLC6A5KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |