Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 14/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.45 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738979 | 0.90 | EZH2 (0.85) | EZH2MAPK14 | |
| SCHEMBL8739042 | 0.90 | EZH2 (1.00) | EZH2 | |
| SCHEMBL8739245 | 0.82 | EZH2 (0.77) | EZH2KDM4EALDH1A1SLC6A5 | |
| SCHEMBL8738277 | 0.82 | EZH2 (0.77) | EZH2ALDH1A1 | |
| SCHEMBL8739720 | 0.81 | EZH2 (0.82) | EZH2 | |
| SCHEMBL8738275 | 0.80 | EZH2 (0.73) | EZH2 | |
| SCHEMBL8738695 | 0.80 | EZH2 (0.91) | EZH2 | |
| SCHEMBL8738144 | 0.80 | EZH2 (1.00) | EZH2 | |
| SCHEMBL8738647 | 0.78 | EZH2 (0.75) | EZH2 | |
| SCHEMBL8739252 | 0.78 | EZH2 (0.64) | EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |