Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.59 |
| ▸ | ZAP70 | P43403 | 5/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12137100 | 0.82 | SYK (0.79) | SYKZAP70KCNH2AURKB | |
| SCHEMBL1354433 | 0.73 | SYK (0.86) | SYKZAP70KCNH2AURKB | |
| SCHEMBL4716047 | 0.70 | SYK (1.00) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL12137210 | 0.69 | SYK (0.71) | SYKKCNH2AURKB | |
| SCHEMBL29794716 | 0.69 | SYK (1.00) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL2383949 | 0.69 | SYK (1.00) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL1354236 | 0.69 | SYK (1.00) | SYKZAP70KCNH2AURKB | |
| SCHEMBL14657302 | 0.68 | SYK (0.75) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL1353649 | 0.68 | SYK (1.00) | SYKZAP70KCNH2AURKB | |
| SCHEMBL13733951 | 0.67 | SYK (0.69) | SYKZAP70KCNH2AURKBCAMK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318755-B2 | Inhibitors of SYK and JAK protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120130073-A1 | INHIBITORS OF SYK AND JAK PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-8063058-B2 | Inhibitors of syk and JAK protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100048567-A1 | Inhibitors of syk and JAK protein kinases | PORTOLA PHARMACEUTICALS INC. (US) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130073-A1 | INHIBITORS OF SYK AND JAK PROTEIN KINASES | SYK, BTK, JAK1 | SYK 1/4885ZAP70 12/4885KCNH2 2494/4885 |
| US-20100048567-A1 | Inhibitors of syk and JAK protein kinases | SYK, BTK, JAK1 | SYK 1/4885ZAP70 12/4885KCNH2 2494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.