SCHEMBL8739720

SCHEMBL8739720

CC1(C)CC(NC(=O)c2ccc(Oc3ccccc3)c(OCc3ccccc3)c2)CC(C)(C)N1

nearest known ligand 0.82

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EZH2 Q15910 18/20 0.82
GLA P06280 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8739042 0.90 EZH2 (1.00) EZH2
SCHEMBL8739474 0.86 EZH2 (0.75) EZH2
SCHEMBL8739015 0.84 EZH2 (0.77) EZH2
SCHEMBL8739466 0.83 EZH2 (0.73) EZH2GLA
SCHEMBL8739283 0.83 EZH2 (0.76) EZH2GLA
SCHEMBL8738997 0.83 EZH2 (1.00) EZH2
SCHEMBL8738695 0.83 EZH2 (0.91) EZH2
SCHEMBL8738979 0.83 EZH2 (0.85) EZH2
SCHEMBL6119756 0.83 EZH2 (0.77) EZH2
SCHEMBL8738256 0.83 EZH2 (0.72) EZH2GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012068589-A2 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS (US) 2012-05-24 WO disclosed