Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 8/20 | 0.55 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.54 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.53 |
| ▸ | F2 | P00734 | 2/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.53 |
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.53 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.53 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.53 |
| ▸ | F10 | P00742 | 1/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.53 |
| ▸ | S100B | P04271 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | AOC1 | P19801 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8739978 | 0.87 | PRSS1 (0.52) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL12348099 | 0.87 | PRSS1 (0.72) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL8740423 | 0.86 | PRSS1 (0.58) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL8739980 | 0.86 | PRMT1 (0.73) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL14540170 | 0.81 | PRSS1 (0.58) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL1820723 | 0.80 | PRSS1 (0.66) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL12793234 | 0.77 | GAA (0.60) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL8740421 | 0.74 | GAA (0.56) | PRSS1TMPRSS2PRMT1F2ST14 | |
| SCHEMBL12014234 | 0.73 | NR1I2 (0.58) | PRSS1 | |
| SCHEMBL12348096 | 0.73 | PRSS1 (0.67) | PRSS1TMPRSS2PRMT1F2ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524732-B2 | Substituted tetrahydroquinolines | MERCK PATENT GMBH (DE) | 2013-09-03 | — | — | US | disclosed |
| US-8207345-B2 | Antitumor agents; use in combination with other drugs such as pentamidine | MERCK PATENT GMBH (DE) | 2012-06-26 | — | — | US | disclosed |
| US-20120130147-A1 | METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS | FINSINGER DIRK (DE) | 2012-05-24 | — | — | US | disclosed |
| US-20100022530-A1 | TETRAHYDROBENZOISOXAZOLE AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN | MERCK PATENT GMBH (DE) | 2010-01-28 | — | — | US | disclosed |
| US-20100022579-A1 | SUBSTITUTED TETRAHYDROQUINOLINES | Merck Patent Gesellschaft mit bescrankter Haftung (DE) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130147-A1 | METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS | TP53, IDH3A, IDH2 | PRSS1 3740/4885TMPRSS2 3181/4885PRMT1 26/4885 |
| US-20100022579-A1 | SUBSTITUTED TETRAHYDROQUINOLINES | RECQL, NDUFS3, TPD52L2 | PRSS1 2081/4885TMPRSS2 2201/4885PRMT1 110/4885 |
| US-20100022530-A1 | TETRAHYDROBENZOISOXAZOLE AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN | CCNB3, TUBB3, CCNB1 | PRSS1 1593/4885TMPRSS2 2740/4885PRMT1 1539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.