Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.51 |
| ▸ | ARG2 | P78540 | 4/20 | 0.35 |
| ▸ | ARG1 | P05089 | 3/20 | 0.35 |
| ▸ | NOS2 | P35228 | 5/20 | 0.35 |
| ▸ | NOS1 | P29475 | 4/20 | 0.35 |
| ▸ | NOS3 | P29474 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL23292473 | 0.89 | GSR (0.65) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL8199478 | 0.89 | GSR (0.65) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL8322630 | 0.89 | GSR (0.65) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL5084114 | 0.85 | GSR (0.59) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL8391129 | 0.85 | GSR (0.59) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL5084119 | 0.85 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL746846 | 0.85 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL21816467 | 0.85 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL1537434 | 0.85 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL746845 | 0.85 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705104-A4 | METHOD OF CANCER TREATMENT | TERMAN DAVID S (US) | 1997-06-18 | — | — | EP | disclosed |
| EP-0705104-A1 | METHOD OF CANCER TREATMENT | TERMAN, David S. (US) | 1996-04-10 | — | — | EP | disclosed |
| WO-1994020124-A1 | METHOD OF CANCER TREATMENT | TERMAN DAVID S (US) | 1994-09-15 | — | — | WO | disclosed |