Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.72 |
| ▸ | CTSK | P43235 | 9/20 | 0.72 |
| ▸ | CTSB | P07858 | 5/20 | 0.72 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 3/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | ACE | P12821 | 2/20 | 0.52 |
| ▸ | MME | P08473 | 1/20 | 0.52 |
| ▸ | CPA1 | P15085 | 1/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.52 |
| ▸ | REN | P00797 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | SDCBP | O00560 | 1/20 | 0.49 |
| ▸ | SDC2 | P34741 | 1/20 | 0.49 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556443 | 0.90 | CTSS (0.68) | CTSSCTSKCTSBPTPN1CTSL | |
| SCHEMBL8740498 | 0.90 | CTSS (0.68) | CTSSCTSKCTSBPTPN1CTSL | |
| SCHEMBL29481445 | 0.89 | CTSS (0.74) | CTSSCTSKCTSBPTPN1CTSL | |
| SCHEMBL29436862 | 0.89 | CTSS (0.74) | CTSSCTSKCTSBPTPN1CTSL | |
| SCHEMBL1519727 | 0.89 | CTSS (0.74) | CTSSCTSKCTSBPTPN1CTSL | |
| SCHEMBL29397962 | 0.89 | CTSS (0.74) | CTSSCTSKCTSBPTPN1CTSL | |
| SCHEMBL1519731 | 0.89 | CTSS (0.74) | CTSSCTSKCTSBPTPN1CTSL | |
| SCHEMBL29401906 | 0.89 | CTSS (0.74) | CTSSCTSKCTSBPTPN1CTSL | |
| SCHEMBL3821361 | 0.89 | CTSS (0.74) | CTSSCTSKCTSBPTPN1CTSL | |
| SCHEMBL25283580 | 0.87 | CTSS (0.68) | CTSSCTSKCTSBCTSLACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5629285-A | Inhibitors of TNF-α secretion | IMMUNEX CORPORATION (US) | 1997-05-13 | — | — | US | disclosed |
| EP-0715619-A4 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORP (US) | 1997-03-19 | — | — | EP | disclosed |
| US-5594106-A | Inhibitors of TNF-α secretion | IMMUNEX CORPORATION (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0715619-A1 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORPORATION (US) | 1996-06-12 | — | — | EP | disclosed |
| WO-1995006031-A1 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORPORATION (US) | 1995-03-02 | — | — | WO | disclosed |