Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 9/20 | 0.68 |
| ▸ | CTSK | P43235 | 7/20 | 0.68 |
| ▸ | CTSB | P07858 | 5/20 | 0.68 |
| ▸ | REN | P00797 | 3/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 3/20 | 0.50 |
| ▸ | MMP9 | P14780 | 2/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | FCER2 | P06734 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | CPA1 | P15085 | 1/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556443 | 1.00 | CTSS (0.68) | CTSSCTSKCTSBRENPTPN1 | |
| SCHEMBL8740495 | 0.90 | CTSS (0.72) | CTSSCTSKCTSBRENPTPN1 | |
| SCHEMBL9331930 | 0.89 | CTSS (0.69) | CTSSCTSKCTSBRENPTPN1 | |
| SCHEMBL7655882 | 0.89 | CTSS (0.69) | CTSSCTSKCTSBRENPTPN1 | |
| SCHEMBL8740509 | 0.89 | CTSS (0.69) | CTSSCTSKCTSBRENPTPN1 | |
| SCHEMBL8740501 | 0.88 | CTSB (0.53) | CTSSCTSKCTSBRENPTPN1 | |
| SCHEMBL8896177 | 0.87 | REN (0.66) | CTSSCTSKCTSBRENCTSL | |
| SCHEMBL16576494 | 0.87 | REN (0.66) | CTSSCTSKCTSBRENCTSL | |
| SCHEMBL5966507 | 0.85 | CTSS (0.74) | CTSSCTSKCTSBPTPN1CTSL | |
| SCHEMBL5557866 | 0.85 | CTSS (0.74) | CTSSCTSKCTSBPTPN1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5629285-A | Inhibitors of TNF-α secretion | IMMUNEX CORPORATION (US) | 1997-05-13 | — | — | US | disclosed |
| EP-0715619-A4 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORP (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0715619-A1 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORPORATION (US) | 1996-06-12 | — | — | EP | disclosed |
| WO-1995006031-A1 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORPORATION (US) | 1995-03-02 | — | — | WO | disclosed |