Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 6/20 | 0.35 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874571 | 0.90 | MAPT (0.38) | KDM4EMAPTHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL875385 | 0.88 | MAPT (0.40) | KDM4EMAPTHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL875479 | 0.86 | NAMPT (0.40) | KDM4EMAPTHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL874210 | 0.86 | MAPT (0.40) | KDM4EMAPTHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL874082 | 0.85 | MAPT (0.38) | KDM4EMAPTHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL874570 | 0.84 | MOK (0.43) | KDM4EMAPTHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL874837 | 0.83 | KMT2A (0.37) | KDM4EMAPTHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL873658 | 0.80 | NAMPT (0.39) | KDM4EMAPTHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL874686 | 0.80 | CYP3A4 (0.42) | CHRNA7NAMPTCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL874025 | 0.79 | NAMPT (0.41) | KDM4EMAPTHPGDSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |