Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875479 | 0.94 | NAMPT (0.40) | NAMPTCHRNA7CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL874516 | 0.91 | NAMPT (0.39) | NAMPTCHRNA7CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL873821 | 0.90 | NAMPT (0.39) | NAMPTCHRNA7CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL875501 | 0.89 | CHRNA7 (0.40) | NAMPTCHRNA7CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL873657 | 0.85 | CYP3A4 (0.41) | NAMPTCHRNA7CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL874059 | 0.84 | NAMPT (0.41) | NAMPTCHRNA7MAPTKDM4EHPGD | |
| SCHEMBL874016 | 0.84 | NAMPT (0.37) | NAMPTCHRNA7KCNH2MAPTSMN1; SMN2 | |
| SCHEMBL874083 | 0.80 | KDM4E (0.38) | NAMPTCHRNA7CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL877181 | 0.80 | NAMPT (0.40) | NAMPTCHRNA7CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL874686 | 0.80 | CYP3A4 (0.42) | NAMPTCHRNA7CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |