Sugi Predict

Sugi Predict / Compounds / SCHEMBL874166

SCHEMBL874166

SCHEMBL874166

COc1cc2nc(-c3ccccc3-c3ccccc3)[nH]c(=O)c2cc1OC

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GUSB P08236 4/20 0.60
▸ TUBB4A P04350 1/20 0.57
▸ TUBB P07437 1/20 0.57
▸ TUBA3C P0DPH7 1/20 0.57
▸ TUBA1B P68363 1/20 0.57
▸ TUBA4A P68366 1/20 0.57
▸ TUBB4B P68371 1/20 0.57
▸ TUBB3 Q13509 1/20 0.57
▸ TUBB2A Q13885 1/20 0.57
▸ TUBB8 Q3ZCM7 1/20 0.57
▸ TUBA3E Q6PEY2 1/20 0.57
▸ TUBA1A Q71U36 1/20 0.57
▸ TUBA1C Q9BQE3 1/20 0.57
▸ TUBB6 Q9BUF5 1/20 0.57
▸ TUBB2B Q9BVA1 1/20 0.57
▸ TUBB1 Q9H4B7 1/20 0.57
▸ KDM4E B2RXH2 2/20 0.54
▸ TDP1 Q9NUW8 1/20 0.54
▸ MEN1 O00255 1/20 0.54
▸ POLB P06746 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL878158 0.91 GUSB (0.62) GUSBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL874336 0.91 GUSB (0.52) GUSBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL259473 0.91 GUSB (0.67) GUSBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL874165 0.88 GUSB (0.68) GUSBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL874164 0.86 GUSB (0.65) GUSBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL874404 0.85 GUSB (0.61) GUSBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL878157 0.81 GUSB (0.69) GUSBCYP1A1CYP1B1CYP1A2TNKS
SCHEMBL874335 0.80 GUSB (0.58) GUSBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL20770807 0.80 MAPT (0.62) GUSBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL878156 0.79 GUSB (0.66) GUSBCYP1A1CYP1B1CYP1A2TNKS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210017166-A1 PHARMACOKINETICALLY IMPROVED COMPOUNDS SURFACE LOGIX LLC (US) 2021-01-21 — — US disclosed
US-10570123-B2 Pharmacokinetically improved compounds SURFACE LOGIX, LLC (US) 2020-02-25 — — US disclosed
US-20190177311-A1 PHARMACOKINETICALLY IMPROVED COMPOUNDS SURFACE LOGIX, INC. 2019-06-13 — — US disclosed
US-20180072710-A1 PHARMACOKINETICALLY IMPROVED COMPOUNDS SURFACE LOGIX INC (US) 2018-03-15 — — US disclosed
US-9440961-B2 Rho-kinase inhibitors and method of preparation SURFACE LOGIX, INC. (US) 2016-09-13 — — US disclosed
US-20150344464-A1 PHARMACOKINETICALLY IMPROVED COMPOUNDS KADMON CORPORATION, LLC 2015-12-03 — — US disclosed
EP-1865958-B1 PHARMACOKINETICALLY IMPROVED COMPOUNDS SURFACE LOGIX INC (US) 2015-07-08 — — EP disclosed
US-8916576-B2 Pharmacokinetically improved compounds SURFACE LOGIX, INC. (US) 2014-12-23 — — US disclosed
CN-101208094-B Pharmacokinetic improved compounds SURFACE LOGIX, INC. (US) 2014-10-15 — — CN disclosed
US-20130131047-A1 PHARMACOKINETICALLY IMPROVED COMPOUNDS SURFACE LOGIX, INC. (US) 2013-05-23 — — US disclosed
US-8357693-B2 Pharmacokinetically improved compounds SURFACE LOGIX, INC. (US) 2013-01-22 — — US disclosed
US-20120202793-A1 RHO KINASE INHIBITORS KADMON CORPORATION, LLC 2012-08-09 — — US disclosed
WO-2012040499-A2 METABOLIC INHIBITORS SURFACE LOGIX, INC. (US) 2012-03-29 — — WO disclosed
EP-2406236-A1 RHO KINASE INHIBITORS Surface Logix, Inc. (US) 2012-01-18 — — EP disclosed
WO-2010104851-A1 RHO KINASE INHIBITORS SURFACE LOGIX, INC. (US) 2010-09-16 — — WO disclosed
US-20100144707-A1 Pharmacokinetically improved compounds SURFACE LOGIX, LLC 2010-06-10 — — US disclosed
WO-2008054599-A2 RHO KINASE INHIBITORS SURFACE LOGIX, INC. (US) 2008-05-08 — — WO disclosed
EP-1865958-A2 PHARMACOKINETICALLY IMPROVED COMPOUNDS Surface Logix, Inc. (US) 2007-12-19 — — EP disclosed
WO-2006105081-A2 PHARMACOKINETICALLY IMPROVED COMPOUNDS SURFACE LOGIX, INC. (US) 2006-10-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180072710-A1 PHARMACOKINETICALLY IMPROVED COMPOUNDS ROCK2, ROCK1, RHOT2 GUSB 895/4885TUBB4A 1862/4885TUBB 1095/4885
US-20190177311-A1 PHARMACOKINETICALLY IMPROVED COMPOUNDS ROCK2, ROCK1, RHOT2 GUSB 895/4885TUBB4A 1862/4885TUBB 1095/4885
US-20130131047-A1 PHARMACOKINETICALLY IMPROVED COMPOUNDS ROCK2, ROCK1, RHOT2 GUSB 895/4885TUBB4A 1862/4885TUBB 1095/4885
US-20150344464-A1 PHARMACOKINETICALLY IMPROVED COMPOUNDS ROCK2, ROCK1, RHOT2 GUSB 895/4885TUBB4A 1862/4885TUBB 1095/4885
US-20210017166-A1 PHARMACOKINETICALLY IMPROVED COMPOUNDS ROCK2, ROCK1, RHOT2 GUSB 895/4885TUBB4A 1862/4885TUBB 1095/4885
US-20100144707-A1 Pharmacokinetically improved compounds ROCK2, ROCK1, RHOT2 GUSB 895/4885TUBB4A 1862/4885TUBB 1095/4885
US-10570123-B2 Pharmacokinetically improved compounds ROCK2, ROCK1, RHOT2 GUSB 895/4885TUBB4A 1862/4885TUBB 1095/4885
US-20120202793-A1 RHO KINASE INHIBITORS ROCK2, ROCK1, RHOA GUSB 3229/4885TUBB4A 2728/4885TUBB 1771/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.