Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 7/20 | 0.39 |
| ▸ | PPARD | Q03181 | 7/20 | 0.39 |
| ▸ | PPARA | Q07869 | 7/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | TLR2 | O60603 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17910033 | 0.91 | EPHX1 (0.43) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL9582577 | 0.87 | TSHR (0.38) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL31554981 | 0.85 | LMNA (0.34) | TSHRLMNANFKB1PMP22HDAC11 | |
| SCHEMBL19148632 | 0.85 | ALDH1A1 (0.39) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL15281942 | 0.84 | LMNA (0.33) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL19148633 | 0.83 | ALDH1A1 (0.42) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL668614 | 0.83 | ALDH1A1 (0.42) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL7654077 | 0.80 | CHRM3 (0.37) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL7654073 | 0.80 | CHRM3 (0.37) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL7662667 | 0.80 | CHRM3 (0.37) | TSHRLMNANFKB1PMP22GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2618824-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF DIABETES AND DYSLIPIDEMIA | Kareus Therapeutics SA (FR) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040177-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF DIABETES AND DYSLIPIDEMIA | KAREUS THERAPEUTICS, SA (CH) | 2012-03-29 | — | — | WO | disclosed |