Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16848072 | 0.76 | TSHR (0.56) | TSHRALDH1A1AOC3CARM1PRMT6 | |
| SCHEMBL1165535 | 0.76 | TSHR (0.56) | TSHRALDH1A1AOC3CARM1PRMT6 | |
| SCHEMBL8221762 | 0.74 | TSHR (0.48) | TSHRALDH1A1AOC3CARM1PRMT6 | |
| SCHEMBL24688902 | 0.72 | ALDH1A1 (0.52) | TSHRALDH1A1AOC3CARM1PRMT6 | |
| SCHEMBL4696748 | 0.72 | TSHR (0.52) | TSHRALDH1A1AOC3CARM1PRMT6 | |
| SCHEMBL10776435 | 0.72 | ALDH1A1 (0.52) | TSHRALDH1A1AOC3CARM1PRMT6 | |
| Propane SCHEMBL7131520 | 0.72 | TSHR (0.90) | TSHRALDH1A1AOC3CARM1PRMT6 | |
| SCHEMBL11352917 | 0.72 | ALDH1A1 (0.64) | TSHRALDH1A1AOC3CARM1PRMT6 | |
| Propane SCHEMBL29199487 | 0.72 | TSHR (0.90) | TSHRALDH1A1AOC3CARM1PRMT6 | |
| SCHEMBL17546663 | 0.71 | ALDH1A1 (0.50) | TSHRALDH1A1AOC3CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514794-A | DERIVATIZED DRUGS WITH MALONATE LINKER, THE DRUG BEING LINKED THROUGH METHYLENE TO THE 2-POSITION CARBON OF MALONATE; THESE ARE INTERMEDIATES FOR THE CONJUGATES | ELI LILLY AND COMPANY (US) | 1996-05-07 | — | — | US | claimed |
| EP-0368668-B1 | Antibody-drug conjugates | LILLY CO ELI (US) | 1997-01-02 | — | — | EP | disclosed |
| US-5514794-A | DERIVATIZED DRUGS WITH MALONATE LINKER, THE DRUG BEING LINKED THROUGH METHYLENE TO THE 2-POSITION CARBON OF MALONATE; THESE ARE INTERMEDIATES FOR THE CONJUGATES | ELI LILLY AND COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0622084-A1 | Antibody-drug conjugates | ELI LILLY AND COMPANY (US) | 1994-11-02 | — | — | EP | disclosed |
| US-5010176-A | Malonate linker | ELI LILLY AND COMPANY (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0368668-A2 | Antibody-drug conjugates | ELI LILLY AND COMPANY (US) | 1990-05-16 | — | — | EP | disclosed |