Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.38 |
| ▸ | ALB | P02768 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 7/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14639387 | 0.81 | FGFR1 (0.42) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL5180810 | 0.78 | FGFR1 (0.46) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL8743549 | 0.77 | MAOA (0.35) | FGFR1SLC22A6EP300HDAC1HDAC6 | |
| SCHEMBL10436367 | 0.77 | FGFR1 (0.42) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL3680116 | 0.76 | FGFR1 (0.52) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL236000 | 0.76 | FGFR1 (0.51) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL16978939 | 0.74 | FGFR1 (0.42) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL12261276 | 0.73 | FGFR1 (0.47) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL17372300 | 0.72 | FGFR1 (0.44) | FGFR1SLC22A6PDE3APDE4DSLC29A1 | |
| SCHEMBL1892698 | 0.72 | FGFR1 (0.44) | FGFR1SLC22A6PDE3ALMNACACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335770-B1 | Novel fluorophosphonate nucleotide derivatives | MERRELL PHARMA INC (US) | 1997-01-15 | — | — | EP | disclosed |
| EP-0339161-A1 | Novel fluorophosphonate nucleotide derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-11-02 | — | — | EP | disclosed |
| EP-0335770-A2 | Novel fluorophosphonate nucleotide derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1989-10-04 | — | — | EP | disclosed |