Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.36 |
| ▸ | CBFB | Q13951 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16178955 | 0.78 | KIF11 (0.45) | KIF11TRPA1SCN5ASCN9ACES1 | |
| SCHEMBL874384 | 0.76 | CES1 (0.43) | KIF11TRPA1SCN5ASCN9AKDM4E | |
| SCHEMBL203008 | 0.74 | KIF11 (0.41) | KIF11TRPA1SCN5ASCN9AKDM4E | |
| SCHEMBL12515210 | 0.72 | TRPA1 (0.52) | KIF11TRPA1SCN5ASCN9AKDM4E | |
| SCHEMBL2856373 | 0.71 | TRPA1 (0.51) | KIF11TRPA1SCN5ASCN9AGSK3B | |
| SCHEMBL10883616 | 0.70 | DAO (0.47) | KDM4EGSK3BKMT2A | |
| SCHEMBL10987571 | 0.70 | JAK2 (0.50) | METAP2GSK3BABL1 | |
| SCHEMBL3119854 | 0.70 | KIF11 (0.64) | KIF11TRPA1SCN5ASCN9AKDM4E | |
| SCHEMBL21145515 | 0.69 | HSD17B10 (0.59) | KIF11TRPA1SCN5ASCN9AKDM4E | |
| SCHEMBL7033184 | 0.69 | KIF11 (0.58) | KIF11TRPA1SCN5ASCN9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619179-A1 | MATRIX METALLOPROTEINASE INHIBITORS | Ranbaxy Laboratories Limited (IN) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038944-A1 | MATRIX METALLOPROTEINASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-03-29 | — | — | WO | disclosed |