SCHEMBL874408

SCHEMBL874408

O=C1CCCN1CCBr

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL990667 0.93 L3MBTL1 (0.46)
SCHEMBL9321537 0.91 L3MBTL1 (0.49)
SCHEMBL7341152 0.87 PIK3CD (0.47)
SCHEMBL261644 0.85 PIK3CD (0.58)
SCHEMBL7622769 0.85 ADRA1B (0.46)
SCHEMBL5424673 0.81 PIK3CD (0.54)
SCHEMBL7622224 0.81
SCHEMBL10978509 0.81 L3MBTL1 (0.43)
SCHEMBL7625589 0.79 L3MBTL1 (0.42)
SCHEMBL989008 0.79 PIK3CD (0.52)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 134 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250376482-A1 TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER HOFFMANN-LA ROCHE INC. (US) 2025-12-11 US disclosed
WO-2025119893-A1 SUBSTITUTED BICYCLIC COMPOUNDS MERCK PATENT GMBH (DE) 2025-06-12 WO disclosed
WO-2025072539-A1 AMINO ACID COMPOUNDS WITH NITROGEN LINKERS AND USES THEREOF PLIANT THERAPEUTICS, INC. (US) 2025-04-03 WO disclosed
US-12247036-B2 Tricyclic compounds for the treatment of cancer HOFFMANN-LA ROCHE INC. (US) 2025-03-11 US disclosed
US-20240417410-A1 TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER HOFFMANN-LA ROCHE INC. (US) 2024-12-19 US disclosed
EP-4469164-A1 TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER F. Hoffmann-La Roche AG (CH) 2024-12-04 EP disclosed
WO-2024169914-A1 TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER F. HOFFMANN-LA ROCHE AG (CH) 2024-08-22 WO disclosed
WO-2023154344-A1 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-08-17 WO disclosed
CN-110831942-B Fused indazolopyridinone compounds as antiviral agents 诺华股份有限公司 2023-04-04 CN disclosed
US-11420963-B2 Rebamipide prodrugs, preparation method and use thereof SAMJIN PHARMACEUTICAL CO., LTD. (KR) 2022-08-23 US disclosed
WO-2009139834-A1 BIOACTIVE COMPOUNDS FOR TREATMENT OF CANCER AND NEURODEGENERATIVE DISEASES PONIARD PHARMACEUTICALS, INC. (US) 2009-11-19 WO disclosed
US-20090239854-A1 Tetracyclic compounds MEDIVATION TECHNOLOGIES, INC. 2009-09-24 US disclosed
WO-2009055828-A1 NEW TETRACYCLIC COMPOUNDS MEDIVATION TECHNOLOGIES, INC. (US) 2009-04-30 WO disclosed
CN-101208094-A Pharmacokinetic improved compounds SURFACE LOGIX INC (US) 2008-06-25 CN disclosed
EP-1865958-A2 PHARMACOKINETICALLY IMPROVED COMPOUNDS Surface Logix, Inc. (US) 2007-12-19 EP disclosed
WO-2006105081-A2 PHARMACOKINETICALLY IMPROVED COMPOUNDS SURFACE LOGIX, INC. (US) 2006-10-05 WO disclosed
EP-0307423-A4 MANUFACTURE OF HALOALKYL LACTAMS 1990-12-05 EP disclosed
EP-0307423-A1 MANUFACTURE OF HALOALKYL LACTAMS GAF CHEMICALS CORPORATION (US) 1989-03-22 EP disclosed
US-4792604-A Manufacture of haloalkyl lactams GAF CORPORATION (US) 1988-12-20 US disclosed
WO-1988007039-A1 MANUFACTURE OF HALOALKYL LACTAMS GAF CORPORATION (US) 1988-09-22 WO disclosed