SCHEMBL8744103

SCHEMBL8744103

O=C(O)c1cc(Cl)c([N+](=O)[O-])cc1Cl.O=C(O)c1cc([N+](=O)[O-])c(Cl)cc1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.50
CYP3A4 P08684 1/20 0.50
VCAM1 P19320 2/20 0.46
TSHR P16473 2/20 0.45
SLC25A1 P53007 1/20 0.44
DTYMK P23919 1/20 0.44
MAPK1 P28482 1/20 0.43
CA12 O43570 2/20 0.42
CA9 Q16790 2/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA3 P07451 1/20 0.42
CA4 P22748 1/20 0.42
CA6 P23280 1/20 0.42
CA5A P35218 1/20 0.42
CA7 P43166 1/20 0.42
CA13 Q8N1Q1 1/20 0.42
CISD1 Q9NZ45 1/20 0.42
CA14 Q9ULX7 1/20 0.42
CA5B Q9Y2D0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7749601 0.96 ALDH1A1 (0.53) ALDH1A1CYP3A4VCAM1TSHRSLC25A1
SCHEMBL613001 0.96 ALDH1A1 (0.53) ALDH1A1CYP3A4VCAM1TSHRSLC25A1
SCHEMBL611920 0.95 ALDH1A1 (0.51) ALDH1A1CYP3A4VCAM1TSHRSLC25A1
Hydrochloric Acid SCHEMBL11773238 0.95 ALDH1A1 (0.51) ALDH1A1CYP3A4VCAM1TSHRSLC25A1
SCHEMBL1790306 0.91 TSHR (0.49) ALDH1A1CYP3A4VCAM1TSHRSLC25A1
SCHEMBL2894347 0.89 DTYMK (0.50) ALDH1A1CYP3A4VCAM1TSHRSLC25A1
SCHEMBL2977714 0.85 DTYMK (0.50) ALDH1A1CYP3A4VCAM1TSHRSLC25A1
SCHEMBL29596737 0.85 DTYMK (0.50) ALDH1A1CYP3A4VCAM1TSHRSLC25A1
SCHEMBL3902768 0.83 DTYMK (0.51) ALDH1A1CYP3A4VCAM1TSHRSLC25A1
SCHEMBL22163985 0.83 CA12 (0.52) ALDH1A1CYP3A4VCAM1TSHRSLC25A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0751768-A1 ANTI-VIRAL AND ANTI-CANCER AGENTS RADOPATH LIMITED (GB) 1997-01-08 EP disclosed
WO-1995024897-A1 ANTI-VIRAL AND ANTI-CANCER AGENTS RADOPATH LIMITED (GB) 1995-09-21 WO disclosed