Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | DTYMK | P23919 | 1/20 | 0.45 |
| ▸ | SLC25A1 | P53007 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.43 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL613001 | 0.98 | ALDH1A1 (0.53) | ALDH1A1CYP3A4VCAM1TSHRDTYMK | |
| Hydrochloric Acid SCHEMBL11773238 | 0.96 | ALDH1A1 (0.51) | ALDH1A1CYP3A4VCAM1TSHRDTYMK | |
| SCHEMBL8744103 | 0.95 | ALDH1A1 (0.50) | ALDH1A1CYP3A4VCAM1TSHRDTYMK | |
| SCHEMBL7749601 | 0.91 | ALDH1A1 (0.53) | ALDH1A1CYP3A4VCAM1TSHRDTYMK | |
| SCHEMBL1790306 | 0.89 | TSHR (0.49) | ALDH1A1CYP3A4VCAM1TSHRDTYMK | |
| SCHEMBL2894347 | 0.87 | DTYMK (0.50) | ALDH1A1CYP3A4VCAM1TSHRDTYMK | |
| SCHEMBL1787500 | 0.84 | ALDH1A1 (0.50) | ALDH1A1CYP3A4VCAM1TSHRDTYMK | |
| SCHEMBL27639571 | 0.84 | ALDH1A1 (0.54) | ALDH1A1CYP3A4VCAM1TSHRDTYMK | |
| SCHEMBL10562304 | 0.83 | VCAM1 (0.49) | ALDH1A1CYP3A4VCAM1TSHRMAPK1 | |
| SCHEMBL29596737 | 0.83 | DTYMK (0.50) | ALDH1A1CYP3A4VCAM1TSHRDTYMK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379510-B1 | QUINAZOLINONE COMPOUNDS | PRANA BIOTECHNOLOGY LTD (AU) | 2016-10-26 | — | — | EP | disclosed |
| US-20150359796-A1 | QUINAZOLINONE COMPOUNDS | PRANA BIOTECHNOLOGY LIMITED (AU) | 2015-12-17 | — | — | US | disclosed |
| US-9145375-B2 | Quinazolinone compounds | PRANA BIOTECHNOLOGY LIMITED (AU) | 2015-09-29 | — | — | US | disclosed |
| US-20150025072-A1 | QUINAZOLINONE COMPOUNDS | PRANA BIOTECHNOLOGY LIMITED (AU) | 2015-01-22 | — | — | US | disclosed |
| US-8889695-B2 | Quinazolinone compounds | PRANA BIOTECHNOLOGY LIMITED (AU) | 2014-11-18 | — | — | US | disclosed |
| US-20120040980-A1 | QUINAZOLINONE COMPOUNDS | PRANA BIOTECHNOLOGY LIMITED (AU) | 2012-02-16 | — | — | US | disclosed |
| EP-2379510-A1 | QUINAZOLINONE COMPOUNDS | Prana Biotechnology Ltd (AU) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010071944-A1 | QUINAZOLINONE COMPOUNDS | PRANA BIOTECHNOLOGY LIMITED (AU) | 2010-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150359796-A1 | QUINAZOLINONE COMPOUNDS | PARK7, SNCA, NDUFV2 | ALDH1A1 866/4885CYP3A4 253/4885VCAM1 4362/4885 |
| US-20150025072-A1 | QUINAZOLINONE COMPOUNDS | PARK7, SNCA, NQO2 | ALDH1A1 937/4885CYP3A4 234/4885VCAM1 4417/4885 |
| US-20120040980-A1 | QUINAZOLINONE COMPOUNDS | PARK7, SNCA, NQO2 | ALDH1A1 937/4885CYP3A4 234/4885VCAM1 4417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.