SCHEMBL8744185

SCHEMBL8744185

CCCC(=O)OC/C=C/COC(=O)CCC

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.52
TSHR P16473 3/20 0.48
DGKA P23743 2/20 0.41
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
FFAR3 O14843 3/20 0.38
HDAC3 O15379 3/20 0.38
HDAC1 Q13547 3/20 0.38
HDAC2 Q92769 3/20 0.38
HDAC8 Q9BY41 3/20 0.38
PAM P19021 2/20 0.38
NR1I2 O75469 1/20 0.37
PGR P06401 1/20 0.37
ADORA3 P0DMS8 1/20 0.37
PTGS2 P35354 1/20 0.37
PDE4D Q08499 1/20 0.37
MGLL Q99685 1/20 0.37
CYP1A2 P05177 1/20 0.37
MAPT P10636 2/20 0.36
THRB P10828 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12662617 1.00 ALDH1A1 (0.52) ALDH1A1TSHRDGKACES2CES1
SCHEMBL8744187 1.00 ALDH1A1 (0.52) ALDH1A1TSHRDGKACES2CES1
SCHEMBL28158347 0.93 ALDH1A1 (0.46) ALDH1A1TSHRDGKACES2CES1
SCHEMBL873582 0.91 ALDH1A1 (0.44) ALDH1A1TSHRDGKANR1I2PGR
SCHEMBL873581 0.91 ALDH1A1 (0.44) ALDH1A1TSHRDGKANR1I2PGR
SCHEMBL1695438 0.91 ALDH1A1 (0.48) ALDH1A1TSHRDGKACES2CES1
SCHEMBL2436353 0.91 ALDH1A1 (0.48) ALDH1A1TSHRDGKACES2CES1
SCHEMBL18894521 0.89 ALDH1A1 (0.46) ALDH1A1TSHRDGKACES2CES1
SCHEMBL29119254 0.88 MGLL (0.49) ALDH1A1TSHRDGKANR1I2PGR
SCHEMBL29539414 0.88 MGLL (0.49) ALDH1A1TSHRDGKANR1I2PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4544767-A HYDROGENATION CATALYST PHILLIPS PETROLEUM COMPANY (US) 1985-10-01 US claimed
US-7884281-B2 electroconductive polymers, electron acceptors and an antenna porphyrin aggregates, used in solar cells having solar radiation usage efficiency and exhibits stability SONY CORPORATION (JP) 2011-02-08 US disclosed
EP-0612720-B1 Process for producing 1,4-dicyano-2-butene SUMITOMO CHEMICAL CO (JP) 1997-01-08 EP disclosed
US-5463103-A Reacting butene derivative with hydrogen cyanide in presence of catalyst prepared from cuprous halide, lower alkylamine hydrohalide and Lewis acid or basic acetate, carbonate or bicarbonate SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-10-31 US disclosed
EP-0612720-A1 Process for producing 1,4-dicyano-2-butene SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-08-31 EP disclosed
US-4544767-A HYDROGENATION CATALYST PHILLIPS PETROLEUM COMPANY (US) 1985-10-01 US disclosed