Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 4/20 | 0.56 |
| ▸ | HTR1A | P08908 | 5/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744497 | 0.93 | SLC6A4 (0.61) | SLC6A4DRD4DRD3HTR1AHTR2A | |
| SCHEMBL8744499 | 0.86 | DRD4 (0.58) | SLC6A4DRD4DRD3HTR1AHTR2A | |
| SCHEMBL8744567 | 0.83 | HTR1A (0.68) | SLC6A4DRD4DRD3HTR1AHTR2A | |
| SCHEMBL8744496 | 0.80 | HTR1A (0.64) | DRD4DRD3HTR1AHTR2ADRD2 | |
| SCHEMBL8744492 | 0.76 | HTR1A (0.70) | SLC6A4DRD4DRD3HTR1AHTR2A | |
| SCHEMBL8744498 | 0.75 | HTR1A (0.49) | DRD4DRD3HTR1AHTR2ADRD2 | |
| SCHEMBL8744531 | 0.74 | HTR1A (0.61) | DRD4DRD3HTR1AHTR2ADRD2 | |
| SCHEMBL14761329 | 0.74 | HTR1A (0.67) | SLC6A4DRD4DRD3HTR1AHTR2A | |
| SCHEMBL8744494 | 0.73 | DRD4 (0.53) | DRD4DRD3HTR1AHTR2ADRD2 | |
| SCHEMBL4006809 | 0.73 | DRD4 (0.76) | SLC6A4DRD4DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751939-A1 | NAPHTHYLAMIDES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1997-01-08 | — | — | EP | claimed |
| EP-0751939-A1 | NAPHTHYLAMIDES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1997-01-08 | — | — | EP | disclosed |