Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.68 |
| ▸ | DRD2 | P14416 | 9/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.68 |
| ▸ | DRD4 | P21917 | 5/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.60 |
| ▸ | DRD3 | P35462 | 4/20 | 0.60 |
| ▸ | DRD1 | P21728 | 2/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.60 |
| ▸ | HTR2B | P41595 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744492 | 0.93 | HTR1A (0.70) | HTR1ADRD2ADRA2ADRD4ADRA1A | |
| SCHEMBL8744556 | 0.86 | DRD2 (0.68) | HTR1ADRD2ADRA2ADRD4ADRA1A | |
| SCHEMBL8744506 | 0.83 | SLC6A4 (0.59) | HTR1ADRD2ADRA2ADRD4DRD3 | |
| SCHEMBL8744494 | 0.80 | DRD4 (0.53) | HTR1ADRD2ADRA2ADRD4DRD3 | |
| SCHEMBL8744496 | 0.79 | HTR1A (0.64) | HTR1ADRD2ADRA2ADRD4ADRA1A | |
| SCHEMBL7703066 | 0.79 | DRD2 (0.85) | HTR1ADRD2ADRA2ADRD4ADRA1A | |
| SCHEMBL8744501 | 0.78 | HTR1A (0.51) | HTR1ADRD2ADRA2ADRD4ADRA1A | |
| SCHEMBL7703331 | 0.78 | DRD3 (0.87) | HTR1ADRD2ADRA2ADRD4ADRA1A | |
| SCHEMBL8744498 | 0.78 | HTR1A (0.49) | HTR1ADRD2ADRA2ADRD4ADRA1A | |
| SCHEMBL10911336 | 0.76 | DRD2 (1.00) | HTR1ADRD2ADRA2ADRD4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751939-A1 | NAPHTHYLAMIDES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1997-01-08 | — | — | EP | claimed |
| EP-0751939-A1 | NAPHTHYLAMIDES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1997-01-08 | — | — | EP | disclosed |