Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 4/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.65 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.65 |
| ▸ | ITGAL | P20701 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | ACE | P12821 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | P4HB | P07237 | 1/20 | 0.59 |
| ▸ | TACR1 | P25103 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744719 | 1.00 | P2RY14 (0.68) | P2RY14KDM4EPOLBTP53ITGB2 | |
| SCHEMBL9595246 | 0.89 | MAPT (0.67) | P2RY14KDM4EPOLBTP53MEN1 | |
| SCHEMBL8744739 | 0.89 | MAPT (0.67) | P2RY14KDM4EPOLBTP53MEN1 | |
| SCHEMBL1458374 | 0.88 | P2RY14 (0.69) | P2RY14KDM4EPOLBTP53ITGB2 | |
| SCHEMBL14815316 | 0.88 | P2RY14 (0.69) | P2RY14KDM4EPOLBTP53ITGB2 | |
| SCHEMBL29987387 | 0.86 | ALOX15 (0.70) | P2RY14POLBTP53ITGB2ICAM1 | |
| SCHEMBL3728145 | 0.86 | ALOX15 (0.70) | P2RY14POLBTP53ITGB2ICAM1 | |
| SCHEMBL13278205 | 0.86 | ALOX15 (0.70) | P2RY14POLBTP53ITGB2ICAM1 | |
| SCHEMBL5129578 | 0.86 | ITGB2 (0.83) | P2RY14KDM4EPOLBTP53ITGB2 | |
| SCHEMBL5129573 | 0.86 | ITGB2 (0.83) | P2RY14KDM4EPOLBTP53ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |