Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744741 | 0.86 | KDM4E (0.33) | SMN1; SMN2L3MBTL1ALDH1A1HTTHPGD | |
| SCHEMBL9369273 | 0.82 | NLRP3 (0.37) | NLRP3SMN1; SMN2L3MBTL1ALDH1A1HTT | |
| SCHEMBL9368867 | 0.81 | HPGD (0.40) | NLRP3SMN1; SMN2L3MBTL1ALDH1A1HTT | |
| SCHEMBL9371951 | 0.81 | CNR2 (0.37) | NLRP3SMN1; SMN2L3MBTL1CNR2ALDH1A1 | |
| SCHEMBL9371953 | 0.80 | NLRP3 (0.35) | NLRP3SMN1; SMN2L3MBTL1ALDH1A1HTT | |
| SCHEMBL9368050 | 0.78 | NLRP3 (0.34) | NLRP3SMN1; SMN2L3MBTL1ALDH1A1HTT | |
| SCHEMBL9368573 | 0.78 | TDP1 (0.38) | NLRP3SMN1; SMN2L3MBTL1ALDH1A1HTT | |
| SCHEMBL9368764 | 0.77 | NLRP3 (0.33) | NLRP3SMN1; SMN2L3MBTL1ALDH1A1HTT | |
| SCHEMBL9368775 | 0.76 | NLRP3 (0.40) | NLRP3SMN1; SMN2L3MBTL1CNR2ALDH1A1 | |
| SCHEMBL9368843 | 0.76 | MEN1 (0.39) | NLRP3SMN1; SMN2L3MBTL1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |