Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744754 | 0.86 | NLRP3 (0.34) | KDM4EL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9371951 | 0.74 | CNR2 (0.37) | L3MBTL1MAPTALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL9844162 | 0.72 | CNR2 (0.38) | POLBMAPTALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL8573718 | 0.70 | ALDH1A1 (0.38) | KDM4EPOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9369273 | 0.70 | NLRP3 (0.37) | KDM4EL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9368867 | 0.69 | HPGD (0.40) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9371953 | 0.68 | NLRP3 (0.35) | KDM4EL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL509440 | 0.67 | KDM4E (0.58) | KDM4EPOLBMAPTALDH1A1HPGD | |
| SCHEMBL9481342 | 0.67 | KDM4E (0.40) | KDM4EPOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8744704 | 0.67 | THRA (0.45) | KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |