Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ERCC1 | P07992 | 5/20 | 0.52 |
| ▸ | ERCC4 | Q92889 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13310056 | 0.87 | GAA (0.54) | GAAKMT2AALDH1A1HTTMEN1 | |
| SCHEMBL13190848 | 0.85 | PPID (0.56) | GAAALDH1A1HTTTDP1P2RX7 | |
| SCHEMBL31441299 | 0.84 | KMT2A (0.57) | GAAERCC1ERCC4KMT2AALDH1A1 | |
| SCHEMBL707398 | 0.84 | KMT2A (0.57) | GAAERCC1ERCC4KMT2AALDH1A1 | |
| SCHEMBL3448919 | 0.83 | NPC1 (0.54) | GAAKMT2AALDH1A1HTTMEN1 | |
| SCHEMBL8424664 | 0.81 | ERCC1 (0.61) | ERCC1ERCC4KMT2AP2RX7NPC1 | |
| SCHEMBL15211291 | 0.80 | PPARD (0.45) | GAAKMT2AALDH1A1HTTKDM4E | |
| SCHEMBL8744740 | 0.80 | ERCC1 (0.59) | ERCC1ERCC4KMT2AALDH1A1P2RX7 | |
| SCHEMBL10900050 | 0.78 | ALDH1A1 (0.45) | GAAERCC1ERCC4KMT2AALDH1A1 | |
| SCHEMBL28224249 | 0.77 | SMN1; SMN2 (0.58) | ERCC1ERCC4KMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |