Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 5/20 | 0.59 |
| ▸ | ERCC4 | Q92889 | 5/20 | 0.59 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.58 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GALR3 | O60755 | 1/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11805152 | 0.84 | SHMT1 (0.49) | ERCC1ERCC4SHMT1SHMT2ALDH1A1 | |
| SCHEMBL8424664 | 0.82 | ERCC1 (0.61) | ERCC1ERCC4HPGDNPC1RAB9A | |
| SCHEMBL29419329 | 0.81 | CHRM1 (0.57) | ERCC1ERCC4ALDH1A1P2RX7 | |
| SCHEMBL260512 | 0.81 | CHRM1 (0.57) | ERCC1ERCC4ALDH1A1P2RX7 | |
| SCHEMBL8744815 | 0.80 | GAA (0.56) | ERCC1ERCC4ALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL2532568 | 0.79 | CHRM1 (0.55) | ERCC1ERCC4ALDH1A1HPGDP2RX7 | |
| SCHEMBL11804145 | 0.79 | SHMT1 (0.50) | ERCC1ERCC4SHMT1SHMT2ALDH1A1 | |
| SCHEMBL4247795 | 0.78 | ERCC1 (0.56) | ERCC1ERCC4ALDH1A1NPC1RAB9A | |
| SCHEMBL9523440 | 0.78 | ALDH1A1 (0.65) | ERCC1ERCC4ALDH1A1NPC1RAB9A | |
| SCHEMBL30545006 | 0.78 | ALDH1A1 (0.65) | ERCC1ERCC4ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |