Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.64 |
| ▸ | TTR | P02766 | 5/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.60 |
| ▸ | DPP4 | P27487 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054536 | 0.84 | EPHX2 (0.72) | APPHSD17B10TDP1TP53ALOX15 | |
| SCHEMBL1299521 | 0.81 | CA12 (0.61) | DPP4AKR1B10AKR1B1HDAC3CA12 | |
| SCHEMBL2547176 | 0.81 | CA12 (0.61) | DPP4AKR1B10AKR1B1HDAC3CA12 | |
| Methylcaffeate SCHEMBL28177340 | 0.81 | APP (0.85) | APPTTRPTPN1DPP4HSD17B10 | |
| SCHEMBL17372826 | 0.81 | APP (0.74) | APPTTRPTPN1DPP4HSD17B10 | |
| SCHEMBL28541801 | 0.81 | APP (0.74) | APPTTRPTPN1DPP4HSD17B10 | |
| SCHEMBL27779815 | 0.81 | APP (0.74) | APPTTRPTPN1DPP4HSD17B10 | |
| SCHEMBL30665840 | 0.81 | AKR1B10 (0.52) | KDM4EAKR1B10AKR1B1MMP1MMP2 | |
| SCHEMBL23681099 | 0.80 | TTR (0.67) | APPTTRPTPN1DPP4HSD17B10 | |
| SCHEMBL30628154 | 0.80 | TTR (0.67) | APPTTRPTPN1DPP4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0754038-A1 | USE OF BENZYLIDENE-MALONONITRILE DERIVATES FOR THE TREATMENT OF LEUKEMIA | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1997-01-22 | — | — | EP | disclosed |
| WO-1995028922-A1 | USE OF BENZYLIDENE-MALONONITRILE DERIVATES FOR THE TREATMENT OF LEUKEMIA | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1995-11-02 | — | — | WO | disclosed |