Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 5/20 | 0.67 |
| ▸ | DPP4 | P27487 | 1/20 | 0.67 |
| ▸ | APP | P05067 | 12/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23681099 | 1.00 | TTR (0.67) | TTRDPP4APPKDM4EALDH1A1 | |
| SCHEMBL20914975 | 0.85 | TTR (0.67) | TTRDPP4APPKDM4EALDH1A1 | |
| SCHEMBL20883234 | 0.83 | APP (0.83) | TTRDPP4APPKDM4EALDH1A1 | |
| SCHEMBL8028584 | 0.83 | APP (0.83) | TTRDPP4APPKDM4EALDH1A1 | |
| SCHEMBL9682411 | 0.82 | APP (0.76) | TTRDPP4APPKDM4EALDH1A1 | |
| SCHEMBL29578214 | 0.82 | APP (0.76) | TTRDPP4APPKDM4EALDH1A1 | |
| Ethyl Caffeate SCHEMBL782032 | 0.80 | TTR (1.00) | TTRDPP4APPAKR1B10AKR1B1 | |
| Ethyl Caffeate SCHEMBL782033 | 0.80 | TTR (1.00) | TTRDPP4APPAKR1B10AKR1B1 | |
| SCHEMBL8745007 | 0.80 | APP (0.64) | TTRDPP4APPKDM4EALDH1A1 | |
| Ethyl Caffeate SCHEMBL22196845 | 0.80 | TTR (1.00) | TTRDPP4APPAKR1B10AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11814621-B2 | Expanding the chemical substrates for genetic code reprogramming | NORTHWESTERN UNIVERSITY (US) | 2023-11-14 | — | — | US | disclosed |
| US-20230295613-A1 | LONG CHAIN CARBON AND CYCLIC AMINO ACIDS SUBSTRATES FOR GENETIC CODE REPROGRAMMING | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2023-09-21 | — | — | US | disclosed |