SCHEMBL8745272

SCHEMBL8745272

COc1ccc2c(C(=O)c3ccc(O)cc3)c(-c3ccccc3OC)oc2c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 6/20 0.60
CYP3A4 P08684 4/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
ALOX15 P16050 2/20 0.53
MAPT P10636 2/20 0.53
CNR1 P21554 1/20 0.53
CASP1 P29466 1/20 0.53
CNR2 P34972 1/20 0.53
CASP7 P55210 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
ALOX5 P09917 1/20 0.53
KDM4E B2RXH2 4/20 0.47
TSHR P16473 2/20 0.47
HTT P42858 1/20 0.47
ALDH1A1 P00352 4/20 0.46
HPGD P15428 3/20 0.46
HSD17B10 Q99714 3/20 0.46
CYP2C19 P33261 2/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9056097 0.86 CYP3A4 (0.50) SLC22A12CYP3A4SMN1; SMN2ALOX15MAPT
SCHEMBL6748804 0.82 CNR2 (0.75) SLC22A12CYP3A4SMN1; SMN2ALOX15MAPT
SCHEMBL15864338 0.80 ALOX5 (0.70) L3MBTL1ALOX5KDM4ETSHRALDH1A1
SCHEMBL5138931 0.79 KDM4E (0.74) CYP3A4SMN1; SMN2ALOX15MAPTCASP1
SCHEMBL6746977 0.77 CNR2 (0.82) SLC22A12CYP3A4SMN1; SMN2ALOX15MAPT
SCHEMBL1287454 0.75 SLC22A12 (1.00) SLC22A12CYP3A4SMN1; SMN2ALOX15MAPT
SCHEMBL8478123 0.74 MEN1 (0.49) SLC22A12CYP3A4SMN1; SMN2MAPTCNR1
SCHEMBL7638171 0.74 CNR2 (0.69) CYP3A4SMN1; SMN2ALOX15MAPTCNR1
SCHEMBL28302190 0.73 ALOX5 (0.73) CYP3A4SMN1; SMN2ALOX5KDM4ETSHR
SCHEMBL15865400 0.72 AR (0.47) CYP3A4SMN1; SMN2ALOX15MAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0736007-A4 NON-PEPTIDE TACHYKININ RECEPTOR ANTAGONISTS LILLY CO ELI (US) 1997-03-19 EP disclosed
EP-0736007-A1 NON-PEPTIDE TACHYKININ RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 1996-10-09 EP disclosed
WO-1995017382-A1 NON-PEPTIDE TACHYKININ RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 1995-06-29 WO disclosed