Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 9/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL882692 | 0.89 | POLB (0.58) | SMN1; SMN2L3MBTL1NAMPTMEN1KMT2A | |
| SCHEMBL874896 | 0.85 | POLB (0.57) | SMN1; SMN2L3MBTL1NAMPTMEN1KMT2A | |
| SCHEMBL12335086 | 0.78 | KMT2A (0.76) | SMN1; SMN2L3MBTL1NAMPTMEN1KMT2A | |
| SCHEMBL882718 | 0.78 | POLB (0.58) | SMN1; SMN2L3MBTL1NAMPTMEN1KMT2A | |
| SCHEMBL874893 | 0.78 | POLB (0.55) | SMN1; SMN2L3MBTL1NAMPTMEN1KMT2A | |
| SCHEMBL5192468 | 0.76 | CYP3A4 (0.56) | SMN1; SMN2MEN1KMT2AHDAC1CYP2C9 | |
| SCHEMBL11614852 | 0.76 | SMN1; SMN2 (0.81) | SMN1; SMN2L3MBTL1NAMPTMEN1KMT2A | |
| SCHEMBL875189 | 0.76 | POLB (0.58) | SMN1; SMN2L3MBTL1NAMPTMEN1KMT2A | |
| SCHEMBL12335465 | 0.76 | NAMPT (0.75) | SMN1; SMN2L3MBTL1NAMPTMEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL29131270 | 0.75 | SMN1; SMN2 (0.79) | SMN1; SMN2L3MBTL1NAMPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |