Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 10/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874893 | 0.91 | POLB (0.55) | POLBSMN1; SMN2L3MBTL1NAMPTKMT2A | |
| SCHEMBL882718 | 0.91 | POLB (0.58) | POLBSMN1; SMN2L3MBTL1NAMPTKMT2A | |
| SCHEMBL874533 | 0.85 | SMN1; SMN2 (0.58) | POLBSMN1; SMN2L3MBTL1NAMPTKMT2A | |
| SCHEMBL875189 | 0.82 | POLB (0.58) | POLBSMN1; SMN2L3MBTL1NAMPTKMT2A | |
| SCHEMBL3649687 | 0.82 | POLB (0.60) | POLBSMN1; SMN2L3MBTL1NAMPTKMT2A | |
| SCHEMBL882692 | 0.79 | POLB (0.58) | POLBSMN1; SMN2L3MBTL1NAMPTKMT2A | |
| SCHEMBL3056014 | 0.77 | NAMPT (0.61) | POLBSMN1; SMN2L3MBTL1NAMPTKMT2A | |
| SCHEMBL874891 | 0.76 | HDAC1 (0.50) | POLBNAMPT | |
| SCHEMBL882700 | 0.76 | POLB (0.60) | POLBL3MBTL1NAMPTKMT2AMEN1 | |
| SCHEMBL875939 | 0.75 | POLB (0.56) | POLBNAMPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |