Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL28203363 | 0.88 | TDP1 (0.48) | TSHRSMN1; SMN2GAAMAPTMEN1 | |
| SCHEMBL143319 | 0.88 | — | — | |
| SCHEMBL30509838 | 0.85 | TDP1 (0.46) | TSHRSMN1; SMN2GAAMAPTMEN1 | |
| SCHEMBL29026140 | 0.85 | TDP1 (0.46) | TSHRSMN1; SMN2GAAMAPTMEN1 | |
| SCHEMBL9013178 | 0.85 | TDP1 (0.46) | TSHRSMN1; SMN2GAAMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL27882982 | 0.85 | TDP1 (0.46) | TSHRSMN1; SMN2GAAMAPTMEN1 | |
| SCHEMBL8834720 | 0.79 | ALDH1A1 (0.62) | TSHRSMN1; SMN2GAAMAPTMEN1 | |
| SCHEMBL9841099 | 0.77 | ACP1 (0.44) | ACP1KEAP1CA1CA2TSHR | |
| SCHEMBL18320618 | 0.77 | CYP3A4 (0.46) | CA1CA2TSHRSMN1; SMN2GAA | |
| Diphenylamine SCHEMBL1008716 | 0.75 | HSD17B10 (0.67) | ACP1KEAP1CA1CA2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0621260-B1 | Process for producing N,N-disubstituted p-phenylenediamine derivative sulphate | WAKO PURE CHEM IND LTD (JP) | 1997-02-05 | — | — | EP | disclosed |
| US-5475140-A | Process for producing N,N-disubstituted p-phenylenediamine derivative sulfate | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1995-12-12 | — | — | US | disclosed |
| EP-0621260-A1 | Process for producing N,N-disubstituted p-phenylenediamine derivative sulphate | WAKO PURE CHEMICAL INDUSTRIES LTD (JP) | 1994-10-26 | — | — | EP | disclosed |