Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.90 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.90 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.90 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL11123544 | 1.00 | TSHR (0.90) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Benzene SCHEMBL10751789 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Pyridine SCHEMBL9037865 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| SCHEMBL34466311 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Pyridine SCHEMBL180431 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| SCHEMBL3052767 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Benzene SCHEMBL1261317 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Pyridine SCHEMBL16 | 0.95 | — | — | |
| Pyridine SCHEMBL1654468 | 0.95 | — | — | |
| Pyridine SCHEMBL933604 | 0.95 | TSHR (1.00) | TSHRNAPRTTDP1NOTUMSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0566371-B1 | Process for converting dimethyl ether to ethylidene diacetate | AIR PROD & CHEM (US) | 1997-01-29 | — | — | EP | disclosed |
| EP-0566370-B1 | Integrated process for synthesizing oxygenated acetyl compounds from synthesis gas via dimethyl ether | AIR PROD & CHEM (US) | 1997-01-29 | — | — | EP | disclosed |
| US-5502243-A | FORMING ETHYLIDENE DIACETATE FROM DIMETHYL ETHER, METHANOL AND SYNTHESIS GAS | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1996-03-26 | — | — | US | disclosed |
| EP-0566370-A2 | Integrated process for synthesizing oxygenated acetyl compounds from synthesis gas via dimethyl ether | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1993-10-20 | — | — | EP | disclosed |
| EP-0566371-A2 | Process for converting dimethyl ether to ethylidene diacetate | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1993-10-20 | — | — | EP | disclosed |
| EP-0262310-A1 | Process for the isomerization of unbranched functionalised compounds with terminal double bonds | HÜLS AKTIENGESELLSCHAFT (DE) | 1988-04-06 | — | — | EP | disclosed |
| US-4664851-A | CATALYTIC HOMOLOGATION | SHELL OIL COMPANY (US) | 1987-05-12 | — | — | US | disclosed |
| US-4640802-A | Process for the co-production of carboxylic acids and carboxylic acid esters | SHELL OIL COMPANY (US) | 1987-02-03 | — | — | US | disclosed |
| EP-0131998-A1 | Process for the preparation of ethanol and/or ethyl acetate | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1985-01-23 | — | — | EP | disclosed |
| US-4429150-A | CATALYTIC CARBONYLATION AND HYDROGENATION OF METHYL ACETATE OR DIMETHYL ETHER IN SULFOLANE | SHELL OIL COMPANY (US) | 1984-01-31 | — | — | US | disclosed |
| US-4365079-A | STEPWISE RECRYSTALLIZATION | ATLANTIC RICHFIELD COMPANY (US) | 1982-12-21 | — | — | US | disclosed |
| EP-0048046-A1 | Method for the manufacture of ethylidene diacetate | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1982-03-24 | — | — | EP | disclosed |
| US-4318860-A | REACTING BUTADIENE AND METHYL 2,4-PENTADIENOATE, PALLADIUM COMPLEX CATALYST | ATLANTIC RICHFIELD COMPANY (US) | 1982-03-09 | — | — | US | disclosed |
| US-4299976-A | PALLADIUM COMPLEX CATALYST | ATLANTIC RICHFIELD COMPANY (US) | 1981-11-10 | — | — | US | disclosed |
| EP-0026393-A2 | Preparation of unsaturated diester precursor for sebacic acid and preparation of sebacic acid esters therefrom | ATLANTIC RICHFIELD COMPANY (US) | 1981-04-08 | — | — | EP | disclosed |
| US-4189599-A | Preparation of dimethyl adipate by the hydrogenation of dimethyl hex-3-endioate | ATLANTIC RICHFIELD COMPANY (US) | 1980-02-19 | — | — | US | disclosed |