Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841203 | 0.83 | SCN9A (0.46) | SCN9ASCN5AKCNH2 | |
| SCHEMBL12503905 | 0.79 | SCN9A (0.67) | SCN9ASCN5AKCNH2CNR1 | |
| SCHEMBL841025 | 0.78 | SCN9A (0.49) | SCN9ASCN5AKCNH2 | |
| SCHEMBL841511 | 0.78 | SCN9A (0.35) | SCN9ASCN5AKCNH2CNR1HTR1A | |
| SCHEMBL841410 | 0.78 | SSTR2 (0.40) | SCN9ASCN5AKCNH2 | |
| Ammonia Solution, Strong SCHEMBL3668899 | 0.77 | SCN9A (0.49) | SCN9ASCN5AKCNH2 | |
| SCHEMBL882619 | 0.77 | SCN9A (0.67) | SCN9ASCN5AKCNH2CNR1 | |
| Ammonia Solution, Strong SCHEMBL3674445 | 0.77 | SSTR2 (0.39) | SCN9ASCN5AKCNH2 | |
| Ammonia Solution, Strong SCHEMBL3673475 | 0.77 | SCN9A (0.35) | SCN9ASCN5AKCNH2CNR1HTR1A | |
| SCHEMBL841453 | 0.76 | ELANE (0.37) | SCN9AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012039657-A1 | NOVEL CHROMANE COMPOUND FOR THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2012-03-29 | — | — | WO | claimed |
| WO-2012039657-A1 | NOVEL CHROMANE COMPOUND FOR THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012039657-A1 | NOVEL CHROMANE COMPOUND FOR THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2012-03-29 | — | — | WO | disclosed |