Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841511 | 0.99 | SCN9A (0.35) | SCN9AKCNH2SCN5ACYP19A1CNR1 | |
| SCHEMBL3673478 | 0.81 | DPP4 (0.33) | — | |
| Ammonia Solution, Strong SCHEMBL3668936 | 0.80 | ELANE (0.37) | HTR1A | |
| SCHEMBL841453 | 0.79 | ELANE (0.37) | SCN9AHTR1A | |
| SCHEMBL841172 | 0.77 | — | — | |
| Ammonia Solution, Strong SCHEMBL3674445 | 0.77 | SSTR2 (0.39) | SCN9AKCNH2SCN5A | |
| Ammonia Solution, Strong SCHEMBL3667283 | 0.77 | SCN5A (0.53) | SCN9AKCNH2SCN5A | |
| SCHEMBL841203 | 0.77 | SCN9A (0.46) | SCN9AKCNH2SCN5A | |
| SCHEMBL874635 | 0.77 | SCN9A (0.52) | SCN9AKCNH2SCN5ACNR1HTR1A | |
| SCHEMBL841410 | 0.76 | SSTR2 (0.40) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |