Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.40 |
| ▸ | CES1 | P23141 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8746364 | 0.98 | TTR (0.39) | CES2CES1TTREPHX1ALB | |
| SCHEMBL8746366 | 0.81 | CES2 (0.38) | CES2CES1TTREPHX1ALB | |
| SCHEMBL9264763 | 0.78 | EPHX1 (0.42) | CES2CES1EPHX1ALBALDH1A1 | |
| SCHEMBL8746349 | 0.78 | CES2 (0.40) | CES2CES1EPHX1ALBCAPN1 | |
| SCHEMBL28924946 | 0.77 | EPHX1 (0.41) | CES2CES1EPHX1ALBALDH1A1 | |
| SCHEMBL11017771 | 0.77 | SUCNR1 (0.42) | EPHX1SUCNR1ALDH1A1 | |
| SCHEMBL8550483 | 0.74 | EPHX1 (0.41) | CES2CES1TTREPHX1ALB | |
| SCHEMBL9255795 | 0.72 | EPHX1 (0.69) | CES2CES1EPHX1SUCNR1POLB | |
| SCHEMBL8550629 | 0.72 | EPHX1 (0.69) | CES2CES1EPHX1SUCNR1POLB | |
| SCHEMBL7771291 | 0.72 | EPHX1 (0.69) | CES2CES1EPHX1SUCNR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0654026-B1 | ISOSERINE DERIVATIVES AND THEIR USE AS LEUKOTRIENE ANTAGONISTS | LEO PHARM PROD LTD (DK) | 1997-02-19 | — | — | EP | disclosed |
| US-5576438-A | LIPOXYGENASE INHIBITORS; ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktiesel Skab) (DK) | 1996-11-19 | — | — | US | disclosed |
| EP-0654026-A1 | ISOSERINE DERIVATIVES AND THEIR USE AS LEUKOTRIENE ANTAGONISTS. | LEO PHARM PROD LTD (DK) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003431-A1 | ISOSERINE DERIVATIVES AND THEIR USE AS LEUKOTRIENE ANTAGONISTS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1994-02-17 | — | — | WO | disclosed |