SCHEMBL8746450

SCHEMBL8746450

CCCOC(=O)C(Cl)(Cl)Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.40
ALDH1A1 P00352 5/20 0.39
LMNA P02545 1/20 0.38
TSHR P16473 2/20 0.36
ESR1 P03372 1/20 0.36
CHRM1 P11229 1/20 0.36
SLC6A2 P23975 1/20 0.36
KDR P35968 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
EPHX1 P07099 1/20 0.34
ATM Q13315 1/20 0.33
KDM4E B2RXH2 1/20 0.32
GLA P06280 1/20 0.32
NAAA Q02083 1/20 0.32
DGKA P23743 1/20 0.32
PPM1B O75688 1/20 0.32
PTPN1 P18031 1/20 0.32
PPP1CC P36873 1/20 0.32
HPGD P15428 1/20 0.31
ACHE P22303 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2000027 0.86 ALDH1A1 (0.54) HCAR2ALDH1A1LMNATSHRESR1
SCHEMBL5611304 0.85 HCAR2 (0.40) HCAR2ALDH1A1LMNATSHRESR1
SCHEMBL9489882 0.84 EPHX1 (0.53) HCAR2ALDH1A1LMNATSHREPHX1
SCHEMBL1457249 0.84 ALDH1A1 (0.37) ALDH1A1TSHR
SCHEMBL7105771 0.83 HCAR2 (0.39) HCAR2ALDH1A1LMNATSHRESR1
SCHEMBL2335011 0.83 HCAR2 (0.39) HCAR2ALDH1A1LMNATSHRESR1
SCHEMBL1456856 0.82 EPHX1 (0.57) HCAR2ALDH1A1LMNATSHREPHX1
SCHEMBL5583745 0.82 EPHX1 (0.57) HCAR2ALDH1A1LMNATSHREPHX1
SCHEMBL987628 0.82 EPHX1 (0.57) HCAR2ALDH1A1LMNATSHREPHX1
SCHEMBL28481544 0.82 EPHX1 (0.57) HCAR2ALDH1A1LMNATSHREPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119371582-A Polybutadiene composite rubber and preparation method thereof, rubber composition and application thereof 中国石油化工股份有限公司 2025-01-28 CN claimed
CN-108929396-B Rare earth metal catalyst system and method for preparing high cis conjugated diene polymer 北京化工大学 2020-07-28 CN claimed
CN-108929396-A A kind of rare-earth metal catalyst system and the method for preparing high-cis conjugated diene polymer 北京化工大学 2018-12-04 CN claimed
CN-105646757-B A kind of preparation method of cationic polymerization system and high degree of unsaturation isoolefin copolymers 中国石油化工股份有限公司 2018-04-13 CN claimed
CN-105646757-A Cationic polymerization system and preparation method of high-unsaturation-degree isoolefin copolymer 中国石油化工股份有限公司 2016-06-08 CN claimed
CN-101927186-B Rare earth catalyst system and method for preparing high cis-1,4-polyisoprene UNIV BEIJING CHEMICAL 2012-01-04 CN claimed
CN-101927186-A Rare earth catalyst system and method for preparing high cis-1,4-polyisoprene UNIV BEIJING CHEMICAL 2010-12-29 CN claimed
EP-0546629-B1 Process for preparing elastomeric copolymers of ethylene with a high tensile strength of the crude product ENICHEM ELASTOMERS (IT) 1997-02-26 EP claimed
EP-0546629-A1 Process for preparing elastomeric copolymers of ethylene with a high tensile strength of the crude product ENICHEM ELASTOMERI S.r.l. (IT) 1993-06-16 EP claimed
EP-0086473-B2 COMPONENTS AND CATALYSTS FOR THE POLYMERIZATION OF OLEFINS Montedison S.p.A. (IT) 1992-11-11 EP claimed
EP-0086473-B1 COMPONENTS AND CATALYSTS FOR THE POLYMERIZATION OF OLEFINS Montedison S.p.A. (IT) 1987-05-20 EP claimed
EP-0086473-A2 Components and catalysts for the polymerization of olefins Montedison S.p.A. (IT) 1983-08-24 EP claimed
CN-119371582-A Polybutadiene composite rubber and preparation method thereof, rubber composition and application thereof 中国石油化工股份有限公司 2025-01-28 CN disclosed
CN-108929396-B Rare earth metal catalyst system and method for preparing high cis conjugated diene polymer 北京化工大学 2020-07-28 CN disclosed
CN-108250371-B Bonding type polymer/silicon dioxide hybrid material and preparation method thereof 北京化工大学 2020-06-02 CN disclosed
CN-108250327-B Functionalized polymer containing silicon and hydroxyl at chain end, preparation method thereof and branched polymer 北京化工大学 2020-04-14 CN disclosed
EP-0086473-B1 COMPONENTS AND CATALYSTS FOR THE POLYMERIZATION OF OLEFINS Montedison S.p.A. (IT) 1987-05-20 EP disclosed
US-4522930-A REACTION PRODUCT OF METALOORGANIC COMPOUND OF ALUMINUM, ELECTRON-DONOR COMPOUND REACTIVE WITH MAGNESIUM CHLORIDE AND A SOLID HALOGENATED TITANIUM COMPOUND MONTEDISON S.P.A. (IT) 1985-06-11 US disclosed
EP-0086473-A2 Components and catalysts for the polymerization of olefins Montedison S.p.A. (IT) 1983-08-24 EP disclosed
US-4293440-A HALOGENATED ALDEHYDE, SULFONATE, OR CARBOXYLATE HALLIBURTON COMPANY (US) 1981-10-06 US disclosed