Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8747091 | 0.88 | KDM4E (0.51) | KDM4EGLARCE1CHRNA7GPR84 | |
| SCHEMBL8747269 | 0.87 | KDM4E (0.45) | KDM4EGLARCE1CHRNA7MEN1 | |
| SCHEMBL8747150 | 0.87 | KDM4E (0.47) | KDM4EGLARCE1CHRNA7GPR84 | |
| SCHEMBL8747275 | 0.85 | KDM4E (0.45) | KDM4EGLARCE1CHRNA7MEN1 | |
| SCHEMBL8747185 | 0.85 | KDM4E (0.48) | KDM4EGLARCE1CHRNA7GPR84 | |
| SCHEMBL8747049 | 0.82 | MAPK10 (0.50) | KDM4EGLARCE1MEN1KMT2A | |
| SCHEMBL8747051 | 0.81 | KDM4E (0.45) | KDM4EGLARCE1CHRNA7GPR84 | |
| SCHEMBL8747302 | 0.75 | RAD52 (0.43) | KDM4EGLARCE1RAD52PKM | |
| SCHEMBL14739313 | 0.75 | MAOA (0.68) | KDM4EGLARCE1CHRNA7GPR84 | |
| SCHEMBL3059339 | 0.75 | MAOA (0.68) | KDM4EGLARCE1CHRNA7GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618900-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1997-03-12 | — | — | EP | disclosed |
| US-5519034-A | ANALGESICS | THE BOOTS COMPANY PLC (GB) | 1996-05-21 | — | — | US | disclosed |
| WO-1993013073-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |