SCHEMBL8747283

SCHEMBL8747283

CN1CCc2cc(O)c(O)cc2C1C1(c2ccc(Cl)c(Cl)c2)CCC1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.45
DRD1 P21728 8/20 0.45
DRD2 P14416 5/20 0.45
CYP2D6 P10635 4/20 0.44
SLC6A2 P23975 4/20 0.44
SLC6A4 P31645 4/20 0.44
SLC6A3 Q01959 4/20 0.44
KCNH2 Q12809 4/20 0.44
CYP2C19 P33261 3/20 0.44
CYP3A4 P08684 3/20 0.44
CYP1A1 P04798 2/20 0.44
CYP1A2 P05177 2/20 0.44
CYP2C9 P11712 1/20 0.44
DRD4 P21917 2/20 0.41
DRD5 P21918 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8747405 0.88 MAOA (0.47) MAOADRD1DRD2DRD4DRD5
Bromide SCHEMBL8747099 0.87 MAOA (0.46) MAOADRD1DRD2DRD4
SCHEMBL8747113 0.87 MAOA (0.46) MAOADRD1DRD2DRD4DRD5
SCHEMBL8747027 0.86 MAOA (0.47) MAOADRD1DRD2DRD4DRD5
SCHEMBL8747031 0.85 MAOA (0.46) MAOADRD1DRD2DRD4DRD5
SCHEMBL9300326 0.85 MAOA (0.48) MAOADRD1DRD2DRD4DRD5
SCHEMBL8747006 0.84 MAOA (0.50) MAOADRD1DRD2DRD4
SCHEMBL8747142 0.84 DRD1 (0.53) DRD1DRD2CYP2D6CYP3A4CYP1A2
SCHEMBL8747060 0.84 CYP2D6 (0.46) MAOADRD1DRD2CYP2D6SLC6A2
SCHEMBL8747015 0.84 MAOA (0.47) MAOADRD1DRD2DRD4DRD5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0618900-B1 SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS KNOLL AG (DE) 1997-03-12 EP disclosed
US-5519034-A ANALGESICS THE BOOTS COMPANY PLC (GB) 1996-05-21 US disclosed
EP-0618900-A1 SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS. BOOTS CO PLC (GB) 1994-10-12 EP disclosed
WO-1993013073-A1 SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS THE BOOTS COMPANY PLC (GB) 1993-07-08 WO disclosed