SCHEMBL8747647

SCHEMBL8747647

Cc1cc(C)c(O)c(C(=O)Cl)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.45
KDM4E B2RXH2 3/20 0.45
GAA P10253 2/20 0.45
LMNA P02545 1/20 0.45
MAPT P10636 1/20 0.45
NR2F2 P24468 1/20 0.44
HMGB1 P09429 1/20 0.41
CXCL12 P48061 1/20 0.41
CA1 P00915 2/20 0.37
CA2 P00918 2/20 0.37
SELL P14151 1/20 0.37
SELP P16109 1/20 0.37
SELE P16581 1/20 0.37
MMP1 P03956 1/20 0.36
MMP2 P08253 1/20 0.36
MMP9 P14780 1/20 0.36
MMP8 P22894 1/20 0.36
MMP13 P45452 1/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29031614 0.89 SELL (0.42) ALDH1A1KDM4EGAALMNAMAPT
SCHEMBL28413744 0.82 ALDH1A1 (0.48) ALDH1A1KDM4EGAALMNAMAPT
SCHEMBL29670017 0.82 ALDH1A1 (0.48) ALDH1A1KDM4EGAALMNAMAPT
SCHEMBL1311974 0.80 KDM4E (0.45) ALDH1A1KDM4ELMNAMAPTCA1
SCHEMBL122472 0.80 HMGB1 (0.62) ALDH1A1KDM4EGAALMNAMAPT
SCHEMBL471443 0.80 KDM4E (0.46) ALDH1A1KDM4EGAALMNAMAPT
SCHEMBL30706280 0.80 HMGB1 (0.62) ALDH1A1KDM4EGAALMNAMAPT
SCHEMBL23685779 0.78 KDM4E (0.50) ALDH1A1KDM4EGAALMNAMAPT
SCHEMBL7175355 0.78 KDM4E (0.44) ALDH1A1KDM4ELMNAMAPTCA1
SCHEMBL6856399 0.78 HMGB1 (0.60) ALDH1A1KDM4EGAALMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0459950-B1 Stabilisation of dyes on polyamide fibres CIBA GEIGY AG (CH) 1997-03-12 EP disclosed
EP-0438381-B1 Stabilization of dyes on polyamide fibres CIBA GEIGY AG (CH) 1995-04-05 EP disclosed
US-5356443-A Treating fiber before fixation step with sterically hindered phenol and sulfo containing compound CIBA-GEIGY CORPORATION (US) 1994-10-18 US disclosed
US-5181935-A THERMAL AND PHOTOCHEMICAL STABILIZATION OF DYEINGS ON POLYAMIDE FIBERS:STERICALLY HINDERED PHENOL AND ULTRA-VIOLET ABSORBER CIBA-GEIGY CORPORATION (US) 1993-01-26 US disclosed
US-5096456-A Exhaust or continuous dyeing; carpets automotive fabrics, brassiers CIBA-GEIGY CORPORATION (US) 1992-03-17 US disclosed
EP-0459950-A1 Stabilisation of dyes on polyamide fibres CIBA-GEIGY AG (CH) 1991-12-04 EP disclosed
EP-0438381-A1 Stabilization of dyes on polyamide fibres CIBA-GEIGY AG (CH) 1991-07-24 EP disclosed