Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 14/20 | 0.56 |
| ▸ | AKT1 | P31749 | 3/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.44 |
| ▸ | ILK | Q13418 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | TTPA | P49638 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8600009 | 0.85 | ALOX5 (0.62) | ALOX5AKT1PDPK1PHLPP1ILK | |
| SCHEMBL6028033 | 0.82 | ALOX5 (0.58) | ALOX5AKT1PDPK1PHLPP1ILK | |
| SCHEMBL6463246 | 0.82 | ALOX5 (0.58) | ALOX5AKT1PDPK1PHLPP1ILK | |
| SCHEMBL6027939 | 0.82 | ALOX5 (0.58) | ALOX5AKT1PDPK1PHLPP1ILK | |
| SCHEMBL8746297 | 0.82 | ALOX5 (0.56) | ALOX5AKT1PDPK1PHLPP1ILK | |
| Bromide SCHEMBL8599204 | 0.81 | ALOX5 (0.56) | ALOX5AKT1PDPK1PHLPP1ILK | |
| Bromide SCHEMBL9096621 | 0.81 | ALOX5 (0.55) | ALOX5AKT1PDPK1PHLPP1ILK | |
| SCHEMBL4643458 | 0.81 | ALOX5 (0.66) | ALOX5 | |
| SCHEMBL8747826 | 0.81 | AKT1 (0.66) | ALOX5AKT1PDPK1PHLPP1ILK | |
| SCHEMBL8747784 | 0.80 | MAPT (0.59) | ALOX5MAPTLMNAMEN1GSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586518-B1 | CHOLESTEROL-LOWERING TOCOPHEROL ANALOGS | MERRELL PHARMA INC (US) | 1997-03-12 | — | — | EP | claimed |
| US-5135945-A | Cholesterol-lowering tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-08-04 | — | — | US | claimed |
| EP-0586518-B1 | CHOLESTEROL-LOWERING TOCOPHEROL ANALOGS | MERRELL PHARMA INC (US) | 1997-03-12 | — | — | EP | disclosed |
| EP-0369874-B1 | Cardioprotective tocopherol analogs | MERRELL DOW PHARMA (US) | 1995-02-22 | — | — | EP | disclosed |
| EP-0586518-A1 | CHOLESTEROL-LOWERING TOCOPHEROL ANALOGS. | MERRELL DOW PHARMA (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021336-A1 | CHOLESTEROL-LOWERING TOCOPHEROL ANALOGS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-12-10 | — | — | WO | disclosed |
| US-5135945-A | Cholesterol-lowering tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0369874-A2 | Cardioprotective tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-05-23 | — | — | EP | disclosed |
| EP-0369082-A1 | Cardioprotective tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-05-23 | — | — | EP | disclosed |