Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888400 | 1.00 | RARB (0.62) | RARBRAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL8075234 | 1.00 | RARB (0.62) | RARBRAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL9272426 | 1.00 | RARB (0.62) | RARBRAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL8631186 | 1.00 | RARB (0.62) | RARBRAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL8918716 | 1.00 | RARB (0.62) | RARBRAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL8713869 | 1.00 | RARB (0.62) | RARBRAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL7723530 | 0.98 | RARB (0.60) | RARBRAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL10793104 | 0.93 | RARB (0.54) | RARBRAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL8917053 | 0.88 | MAPT (0.65) | RARBRAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL7677484 | 0.88 | MAPT (0.65) | RARBRAB9ASMN1; SMN2MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520281-B1 | Optical element for generating short wave laser light | HOFFMANN LA ROCHE (CH) | 1997-03-12 | — | — | EP | disclosed |
| US-5393458-A | Aromatic esters and liquid crystal mixtures containing same | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |
| US-5326498-A | Electrooptics, ferroelectricity | HOFFMANN-LA ROCHE INC. (US) | 1994-07-05 | — | — | US | disclosed |
| US-5180521-A | Liquid crystal displays, cyclohexyl nitriles | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1993-01-19 | — | — | US | disclosed |
| EP-0520281-A2 | Optical element for generating short wave laser light | F. HOFFMANN-LA ROCHE AG (CH) | 1992-12-30 | — | — | EP | disclosed |
| CN-1032435-A | The phenyl trifluoromethyl ethers that replaces | MERCK PATENT GMBH (DE) | 1989-04-19 | — | — | CN | disclosed |
| EP-0220297-A1 | NITROGEN-CONTAINING HETEROCYCLES. | MERCK PATENT GMBH (DE) | 1987-05-06 | — | — | EP | disclosed |
| WO-1986006373-A1 | NITROGEN-CONTAINING HETEROCYCLES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1986-11-06 | — | — | WO | disclosed |