SCHEMBL8748157

SCHEMBL8748157

Oc1ccccc1-c1ncnc(-c2ccccc2)n1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.62
ADORA2A P29274 2/20 0.62
ADORA3 P0DMS8 1/20 0.62
ALOX15 P16050 1/20 0.62
ADORA2B P29275 1/20 0.62
ADORA1 P30542 1/20 0.62
CASP3 P42574 3/20 0.53
SENP8 Q96LD8 3/20 0.53
SENP7 Q9BQF6 3/20 0.53
SENP6 Q9GZR1 3/20 0.53
CHUK O15111 1/20 0.53
TXNRD1 Q16881 1/20 0.53
NOX4 Q9NPH5 1/20 0.53
HPGD P15428 3/20 0.52
ALDH1A1 P00352 2/20 0.52
BCL2L1 Q07817 1/20 0.52
HSD17B10 Q99714 1/20 0.52
LMNA P02545 2/20 0.47
POLB P06746 2/20 0.47
L3MBTL1 Q9Y468 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27881592 0.96 TSHR (0.58) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL195151 0.90 SMN1; SMN2 (0.55) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL29502792 0.90 SMN1; SMN2 (0.55) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL28637685 0.88 ADORA2A (0.49) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL5083129 0.88 ADORA2A (0.57) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL8911208 0.84 ALOX5 (0.56) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL7577322 0.84 TSHR (0.82) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL29481861 0.84 TSHR (0.82) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL296255 0.84 TSHR (0.82) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL30436182 0.82 NPC1 (0.52) TSHRADORA2AADORA3ALOX15ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021144395-A1 CARBOXYLIC DITHIOCARBAMIC ACID ANHYDRIDE COMPOUNDS AND COMPOSITIONS THEREOF FUNDACIÓ INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ICIQ) (ES) 2021-07-22 WO disclosed
US-10738206-B2 Black ceramic additives, pigments, and formulations MELIOR INNOVATIONS, INC. (US) 2020-08-11 US disclosed
US-10590256-B2 Black ceramic additives, pigments, and formulations MELIOR INNOVATIONS, INC. (US) 2020-03-17 US disclosed
US-20190315969-A1 High Temperature Boron Black Ceramic Additives, Pigments, and Formulations MELIOR INNOVATIONS, INC. (US) 2019-10-17 US disclosed
CN-108026352-A Polyacetal resin composition and molded article thereof 旭化成株式会社 2018-05-11 CN disclosed
US-20170253720-A1 BLACK CERAMIC ADDITIVES, PIGMENTS, AND FORMULATIONS MELIOR INNOVATIONS, INC. (US) 2017-09-07 US disclosed
US-20170183514-A1 BLACK CERAMIC ADDITIVES, PIGMENTS, AND FORMULATIONS MELIOR INNOVATIONS, INC. (US) 2017-06-29 US disclosed
CN-106459665-A Black ceramic additives, pigments and formulations 美利尔创新公司 2017-02-22 CN disclosed
EP-3110896-A1 BLACK CERAMIC ADDITIVES, PIGMENTS AND FORMULATIONS Melior Innovations Inc. (US) 2017-01-04 EP disclosed
US-9499677-B2 Black ceramic additives, pigments, and formulations MELIOR INNOVATIONS, INC. (US) 2016-11-22 US disclosed
US-20150252166-A1 BLACK CERAMIC ADDITIVES, PIGMENTS, AND FORMULATIONS MELIOR INNOVATIONS, INC. (US) 2015-09-10 US disclosed
US-20150252171-A1 BLACK CERAMIC ADDITIVES, PIGMENTS, AND FORMULATIONS MELIOR INNOVATIONS, INC. (US) 2015-09-10 US disclosed
US-20150252170-A1 BLACK CERAMIC ADDITIVES, PIGMENTS, AND FORMULATIONS MELIOR INNOVATIONS, INC. (US) 2015-09-10 US disclosed
WO-2015131167-A1 BLACK CERAMIC ADDITIVES, PIGMENTS AND FORMULATIONS MELIOR INNOVATIONS, INC. (US) 2015-09-03 WO disclosed
US-20140362156-A1 Thermal Transfer Ribbon Marking BRADY WORLDWIDE, INC. (US) 2014-12-11 US disclosed
CN-101788795-B Zero-power-consumption standby control device for household appliances UNIV NANJING AERONAUTICS 2012-06-06 CN disclosed
CN-201638038-U Zero-power consumption standby control device of household appliance UNIV NANJING AERONAUTICS 2010-11-17 CN disclosed
CN-101788795-A Zero-power-consumption standby control device for household appliances UNIV NANJING AERONAUTICS 2010-07-28 CN disclosed
CN-101657498-A Products with improved flame retardancy BAYER MATERIALSCIENCE AG DE 2010-02-24 CN disclosed
EP-0762197-A1 Photographic recording material Agfa-Gevaert AG (DE) 1997-03-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150252166-A1 BLACK CERAMIC ADDITIVES, PIGMENTS, AND FORMULATIONS IK, RB1, DOT1L TSHR 4696/4885ADORA2A 4231/4885ADORA3 4331/4885
US-20150252170-A1 BLACK CERAMIC ADDITIVES, PIGMENTS, AND FORMULATIONS IK, RB1, DOT1L TSHR 4696/4885ADORA2A 4231/4885ADORA3 4331/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.