Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.56 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8748256 | 1.00 | GAA (0.63) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8748072 | 0.88 | LTB4R (0.61) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL9133552 | 0.88 | LTB4R (0.61) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8995041 | 0.88 | LTB4R (0.54) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8747955 | 0.87 | LTB4R (0.78) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8748241 | 0.87 | LTB4R (0.78) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8747956 | 0.87 | LTB4R (0.78) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8748238 | 0.87 | LTB4R (0.78) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL7717126 | 0.86 | GAA (0.53) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8747961 | 0.86 | GAA (0.53) | GAARAB9ANPC1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601977-B1 | Aromatic hydroxyamidine derivatives and their use as leukotriene B4 receptor antagonists | CIBA GEIGY AG (CH) | 1997-01-22 | — | — | EP | disclosed |
| US-5455274-A | Leukotriene antagonists; treating rheumatoid arthritis | CIBA-GEIGY CORPORATION (US) | 1995-10-03 | — | — | US | disclosed |