Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.61 |
| ▸ | RXRA | P19793 | 11/20 | 0.60 |
| ▸ | RXRB | P28702 | 9/20 | 0.60 |
| ▸ | RXRG | P48443 | 6/20 | 0.53 |
| ▸ | RARB | P10826 | 10/20 | 0.53 |
| ▸ | RARG | P13631 | 10/20 | 0.53 |
| ▸ | RARA | P10276 | 8/20 | 0.53 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8106548 | 0.87 | CYP3A4 (0.47) | CYP26A1CYP3A4CYP26B1RXRARXRB | |
| SCHEMBL5888064 | 0.80 | RXRA (0.72) | CYP26A1CYP3A4CYP26B1RXRARXRB | |
| SCHEMBL8839242 | 0.79 | RXRA (0.69) | CYP26A1CYP3A4CYP26B1RXRARXRB | |
| SCHEMBL8748720 | 0.78 | CYP26A1 (0.53) | CYP26A1CYP3A4CYP26B1RXRARXRB | |
| SCHEMBL5083937 | 0.78 | RXRA (0.70) | CYP26A1CYP3A4CYP26B1RXRARXRB | |
| SCHEMBL5078263 | 0.77 | RXRA (0.65) | CYP26A1CYP3A4CYP26B1RXRARXRB | |
| SCHEMBL9519749 | 0.76 | RXRA (0.71) | CYP26A1CYP3A4CYP26B1RXRARXRB | |
| SCHEMBL8461581 | 0.76 | CYP26A1 (1.00) | CYP26A1CYP3A4CYP26B1RXRARXRB | |
| SCHEMBL8458824 | 0.76 | RXRA (1.00) | CYP26A1CYP3A4CYP26B1RXRARXRB | |
| SCHEMBL7422602 | 0.76 | RXRA (1.00) | CYP26A1CYP3A4CYP26B1RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661260-B1 | New bi-aromatic compounds derived from amides pharmaceutical compositions and cosmetic compositions containing them and their use | CIRD GALDERMA (FR) | 1997-03-12 | — | — | EP | disclosed |
| EP-0661260-A1 | New bi-aromatic compounds derived from amides pharmaceutical compositions and cosmetic compositions containing them and their use | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1995-07-05 | — | — | EP | disclosed |