Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.50 |
| ▸ | NAMPT | P43490 | 6/20 | 0.48 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874893 | 0.86 | POLB (0.55) | NAMPTPOLB | |
| SCHEMBL875381 | 0.85 | NAMPT (0.47) | HDAC1NAMPTPOLB | |
| SCHEMBL875170 | 0.83 | HDAC1 (0.41) | HDAC1NAMPTIKBKBROCK2 | |
| SCHEMBL874752 | 0.81 | NAMPT (0.52) | HDAC1NAMPTPOLBMAPT | |
| SCHEMBL3061231 | 0.78 | NAMPT (0.53) | HDAC1NAMPTROCK2POLB | |
| SCHEMBL874398 | 0.78 | NAMPT (0.50) | HDAC1NAMPT | |
| SCHEMBL3053572 | 0.77 | NAMPT (0.48) | HDAC1NAMPTROCK2POLB | |
| SCHEMBL874896 | 0.76 | POLB (0.57) | NAMPTPOLB | |
| SCHEMBL874666 | 0.76 | IKBKB (0.55) | IKBKBPOLBMAPT | |
| SCHEMBL882718 | 0.75 | POLB (0.58) | NAMPTROCK2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |