SCHEMBL8749233

SCHEMBL8749233

COC(=O)C(C)Oc1ccc(Cl)c(Oc2ccc(C(F)(F)F)cc2Cl)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 5/20 0.50
MAPT P10636 3/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
HTR2A P28223 1/20 0.45
SLC6A4 P31645 1/20 0.45
KCNH2 Q12809 1/20 0.45
TTR P02766 1/20 0.44
PPOX P50336 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
SCN8A Q9UQD0 1/20 0.44
SCN10A Q9Y5Y9 1/20 0.44
MAPK1 P28482 1/20 0.44
MRGPRX4 Q96LA9 2/20 0.42
LMNA P02545 2/20 0.42
KDM4E B2RXH2 1/20 0.42
GAA P10253 1/20 0.42
HPGD P15428 1/20 0.42
THRB P10828 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11442480 0.92 FFAR1 (0.52) FFAR1MAPTMEN1KMT2AL3MBTL1
SCHEMBL732095 0.91 FFAR1 (0.58) FFAR1MAPTMEN1KMT2AL3MBTL1
SCHEMBL11258317 0.87 FFAR1 (0.54) FFAR1MAPTMEN1KMT2AL3MBTL1
SCHEMBL29382403 0.87 FFAR1 (0.51) FFAR1MAPTMEN1KMT2AL3MBTL1
SCHEMBL147772 0.87 FFAR1 (0.51) FFAR1MAPTMEN1KMT2AL3MBTL1
SCHEMBL941173 0.87 FFAR1 (0.51) FFAR1MAPTMEN1KMT2AL3MBTL1
SCHEMBL8749252 0.86 FFAR1 (0.50) FFAR1MAPTMEN1KMT2AL3MBTL1
SCHEMBL8749291 0.85 FFAR1 (0.49) FFAR1MAPTMEN1KMT2AHTR2A
SCHEMBL7813538 0.85 SCN8A (0.46) FFAR1SCN8ASCN10AMAPK1MRGPRX4
SCHEMBL11436042 0.85 FFAR1 (0.49) FFAR1MAPTMEN1KMT2AHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0768085-A1 ANTIBACTERIAL AGENT DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1997-04-16 EP disclosed
EP-0761215-A1 ANTIBACTERIAL AGENT DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1997-03-12 EP disclosed
EP-0003295-B1 PHENOXY-PHENOXY-ALKYLCARBOXYLIC ACID DERIVATIVES WITH HERBICIDAL ACTIVITY, THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE CIBA-GEIGY AG (CH) 1981-11-25 EP disclosed
EP-0003295-A1 Phenoxy-phenoxy-alkylcarboxylic acid derivatives with herbicidal activity, their preparation, compositions containing them and their use CIBA-GEIGY AG (CH) 1979-08-08 EP disclosed