Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL882769 | 0.89 | HDAC6 (0.43) | PHGDHKMT2ALMNAHDAC6RAB9A | |
| SCHEMBL17593064 | 0.82 | PHGDH (0.50) | PHGDHKMT2ALMNAHDAC6SMN1; SMN2 | |
| SCHEMBL873743 | 0.81 | PHGDH (0.48) | PHGDHKMT2ALMNAHDAC6RAB9A | |
| SCHEMBL25434631 | 0.79 | HDAC6 (0.43) | PHGDHKMT2AHDAC6MAPTALDH1A1 | |
| SCHEMBL2373561 | 0.76 | HTT (0.39) | KMT2ALMNAMEN1ALDH1A1 | |
| SCHEMBL877737 | 0.73 | MMP2 (0.46) | PHGDHKMT2ALMNAMMP1MMP2 | |
| SCHEMBL25433886 | 0.73 | RET (0.46) | PHGDHLMNAMAPTALDH1A1 | |
| SCHEMBL3393979 | 0.71 | PDE4B (0.50) | PHGDHKMT2ARAD51TDP1RAB9A | |
| SCHEMBL882712 | 0.71 | HDAC6 (0.47) | PHGDHHDAC6 | |
| SCHEMBL22592728 | 0.71 | KMT2A (0.41) | PHGDHKMT2ALMNAHDAC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |