Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.48 |
| ▸ | MAOA | P21397 | 3/20 | 0.48 |
| ▸ | PTPRC | P08575 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875019 | 0.71 | MAOB (0.50) | MAOBMAOAPTPRCPTPN1CA2 | |
| SCHEMBL12854020 | 0.71 | MAOB (0.71) | MAOBMAOAPTPRCPTPN1CA2 | |
| SCHEMBL61411 | 0.71 | MAOB (0.71) | MAOBMAOAPTPRCPTPN1CA2 | |
| SCHEMBL6642296 | 0.71 | PTGS2 (0.52) | KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL18984965 | 0.69 | MAOB (0.62) | MAOBMAOAPTPRCPTPN1KMT2A | |
| SCHEMBL712885 | 0.69 | MAOB (0.49) | MAOBMAOAPTPRCPTPN1CA2 | |
| SCHEMBL874838 | 0.69 | MAOB (0.47) | MAOBMAOAPTPRCPTPN1KMT2A | |
| SCHEMBL18015826 | 0.68 | MAOB (0.57) | MAOBMAOAPTPRCPTPN1CA2 | |
| SCHEMBL15636962 | 0.68 | POLB (0.41) | PTPRCKMT2APOLB | |
| SCHEMBL2206820 | 0.68 | PTGS2 (0.37) | MAOBMAOAPTPN1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619200-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040511-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2012-03-29 | — | — | WO | disclosed |