Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 10/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.34 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.34 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.34 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8750759 | 0.87 | KDM4E (0.41) | P2RX7HIF1ASCN2ASCN10AMAPT | |
| SCHEMBL8750765 | 0.84 | KDM4E (0.39) | P2RX7HIF1ASCN2ASCN10AMAPT | |
| SCHEMBL8750860 | 0.82 | HTR3E (0.36) | P2RX7GAASCN2ASCN10A | |
| SCHEMBL8750863 | 0.82 | HTR3E (0.36) | P2RX7GAASCN2ASCN10A | |
| SCHEMBL8750783 | 0.82 | P2RX7 (0.38) | P2RX7HIF1ASCN2ASCN10AMAPT | |
| SCHEMBL8750839 | 0.82 | P2RX7 (0.41) | P2RX7HIF1ASCN2ASCN10AMAPT | |
| SCHEMBL8750762 | 0.81 | HIF1A (0.46) | P2RX7HIF1ASCN2ASCN10AROCK2 | |
| SCHEMBL8750766 | 0.81 | P2RX7 (0.42) | P2RX7HIF1ASCN2ASCN10AMAPT | |
| SCHEMBL8750824 | 0.81 | HIF1A (0.40) | P2RX7HIF1ASCN2ASCN10AROCK2 | |
| SCHEMBL5044056 | 0.80 | HIF1A (0.39) | P2RX7HIF1ASCN2ASCN10AROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0634400-B1 | PYRIDINECARBOXIMIDAMIDE COMPOUND AND USE THEREOF | KIRIN BREWERY (JP) | 1997-04-02 | — | — | EP | disclosed |
| US-5508293-A | TREATING HYPERTENSION, ANGINA PECTORIS | KIRIN BEER KABUSHIKI KAISHA (JP) | 1996-04-16 | — | — | US | disclosed |
| EP-0634400-A1 | PYRIDINECARBOXIMIDAMIDE COMPOUND AND USE THEREOF | KIRIN BEER KABUSHIKI KAISHA (JP) | 1995-01-18 | — | — | EP | disclosed |